Show simple item record

dc.contributor.authorBewick, T
dc.contributor.authorSheppard, C
dc.contributor.authorGreenwood, S
dc.contributor.authorSlack, M
dc.contributor.authorTrotter, C
dc.contributor.authorGeorge, R
dc.contributor.authorLim, WS
dc.date.accessioned2018-05-08T02:29:06Z
dc.date.available2018-05-08T02:29:06Z
dc.date.issued2013
dc.identifier.issn0903-1936
dc.identifier.doi10.1183/09031936.00144712
dc.identifier.urihttp://hdl.handle.net/10072/172028
dc.description.abstractSerotypes 1, 3, 7F and 19A are implicated in childhood pneumococcal para-pneumonic effusion (PPE). It is not known whether the same is true for adult PPE. A prospective cohort study was conducted over a 2-year period. Consecutive adults admitted with community-acquired pneumonia (CAP) were studied. Pneumococcal serotype was identified from urine samples using a multiplex immunoassay. Of 920 patients recruited, 366 had pneumococcal CAP; 100 of these had PPE and a serotype was determined in 73 patients. Factors associated with PPE were age, pneumonia severity index score and serotype. Serotypes most associated with PPE were 1 (18 (45%) out of 40), 19A (9 (45%) out of 20) and 3 (8 (40%) out of 20). Serotypes common in childhood PPE were independently associated with adult PPE (adjusted OR 2.3; p = 0.003). Serotypes not included in the 7-valent pneumococcal conjugate vaccine (PCV) were more likely to be associated with PPE (OR 2.1; p = 0.024) compared with those in the vaccine. Serotypes included in PCV-13 were as likely to be associated with PPE as those that are not (OR 0.8; p = 0.301). Serotypes 1, 3, 7F and 19A are independently associated with adult PPE, a similar finding to childhood PPE. Serotype replacement following pneumococcal vaccine implementation may influence the spectrum of clinical disease.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherEuropean Respiratory Society
dc.relation.ispartofpagefrom733
dc.relation.ispartofpageto741
dc.relation.ispartofissue3
dc.relation.ispartofjournalEuropean Respiratory Journal
dc.relation.ispartofvolume42
dc.subject.fieldofresearchClinical Microbiology
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110303
dc.subject.fieldofresearchcode11
dc.titleSerotypes associated with the development of pneumococcal para-pneumonic effusion in adults
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorSlack, Mary P.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record