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dc.contributor.authorScott, Susana
dc.contributor.authorAltanseseg, Dorjpurev
dc.contributor.authorSodbayer, Demberelsuren
dc.contributor.authorNymadawa, Pagvajav
dc.contributor.authorBulgan, Davaadash
dc.contributor.authorMendsaikhan, Jamsran
dc.contributor.authorWatt, James P
dc.contributor.authorSlack, Mary PE
dc.contributor.authorCarvalho, Maria G
dc.contributor.authorHajjeh, Rana
dc.contributor.authorEdmond, Karen M
dc.description.abstractObjectives: Bacterial meningitis is associated with high mortality and long-term complications. This study assessed the impact of Haemophilus influenzae type b (Hib) conjugate vaccine on childhood bacterial meningitis in Ulaanbaatar, Mongolia. Study design: Prospective, active, population-based surveillance for suspected meningitis in children aged 2-59 months was conducted (February 2002-January 2011) in 6 hospitals. Clinical data, blood, and cerebrospinal fluid were collected. The impact of Hib conjugate vaccine was assessed by comparing Hib and all cause meningitis data in the 3 years preceding pentavalent conjugate vaccine implementation (2002-2004) with 3 years postimplementation (2008-2010). Results: Five hundred eleven cases of suspected meningitis were identified from 2002-2011. Pentavalent conjugate vaccine coverage in December 2005 in Ulaanbaatar city was 97%. The proportion of suspected cases con- firmed as Hib meningitis decreased from 25% (50/201) in the prevaccination era to 2% (4/193) in the postvaccination era (P < .0001). The annual incidence of Hib decreased from 28 cases per 100 000 children in 2002-2005 to 2 per 100 000 in 2008-2010 (P < .0001). Conclusions: This article demonstrates the marked impact of Hib conjugate vaccine introduction on meningitis in Mongolia. It is important to sustain this surveillance system to monitor the long-term impact of Hib conjugate vaccine, as well as other interventions such as pneumococcal and meningococcal vaccines.
dc.relation.ispartofissue1 SUPPL
dc.relation.ispartofjournalJournal of Pediatrics
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine not elsewhere classified
dc.subject.fieldofresearchHuman Movement and Sports Sciences
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.titleImpact of Haemophilus influenzae type b conjugate vaccine in Mongolia: Prospective population-based surveillance, 2002-2010
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSlack, Mary P.

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