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dc.contributor.authorThomas, Matthew F
dc.contributor.authorSheppard, Carmen L
dc.contributor.authorGuiver, Malcolm
dc.contributor.authorSlack, Mary PE
dc.contributor.authorGeorge, Robert C
dc.contributor.authorGorton, Russell
dc.contributor.authorPaton, James Y
dc.contributor.authorSimmister, Clare
dc.contributor.authorCliff, David
dc.contributor.authorElemraid, Mohamed A
dc.contributor.authorClark, Julia E
dc.contributor.authorRushton, Stephen P
dc.contributor.authorSpencer, David Anthony
dc.date.accessioned2018-05-08T02:19:12Z
dc.date.available2018-05-08T02:19:12Z
dc.date.issued2012
dc.identifier.issn0003-9888
dc.identifier.doi10.1136/archdischild-2012-301790
dc.identifier.urihttp://hdl.handle.net/10072/172035
dc.description.abstractIntroduction Invasive pneumococcal disease due to serotype 19A has become a major concern, particularly in the USA and Asia. We describe the characteristics of pneumococcal serotype 19A related empyema and changes in its incidence in the UK. Methods Data from paediatric empyema patients between September 2006 and March 2011 were collected from 17 respiratory centres in the UK. Pneumococcal serotypes were identified as part of the Health Protection Agency enhanced paediatric empyema surveillance programme. Results Four serotypes accounted for over 80% of 136 cases (Serotype 1 : 43%, 3 : 21%, 7 : 11% and 19A:10%). The incidence of empyema due to serotype 19A quadrupled from 0.48 (0.16–1.13) cases per million children in 2006/2007 to 2.02 (1.25–3.09) in 2010/2011. Severity of disease was significantly increased in children with 19A infection when compared to other serotypes. Conclusions The incidence of empyema due to pneumococcal serotype 19A infection has increased significantly and is associated with substantial morbidity.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ Group
dc.relation.ispartofpagefrom1070
dc.relation.ispartofpageto1072
dc.relation.ispartofissue12
dc.relation.ispartofjournalArchives of Disease in Childhood
dc.relation.ispartofvolume97
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleEmergence of pneumococcal 19A empyema in UK children
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSlack, Mary P.


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