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dc.contributor.authorLadhani, Shamez N
dc.contributor.authorCollins, Sarah
dc.contributor.authorVickers, Anna
dc.contributor.authorLitt, David J
dc.contributor.authorCrawford, Carina
dc.contributor.authorRamsay, Mary E
dc.contributor.authorSlack, Mary PE
dc.date.accessioned2018-01-21T22:44:32Z
dc.date.available2018-01-21T22:44:32Z
dc.date.issued2012
dc.identifier.issn1080-6040
dc.identifier.doi10.3201/eid1805.111738
dc.identifier.urihttp://hdl.handle.net/10072/172040
dc.description.abstractHaemophilus influenzae infection causes serious invasive disease, but incidence of the most virulent serotype, Hib, has dropped since introduction of routine Hib vaccination. In England and Wales, the incidence of 2 other serotypes, Hie and Hif, is increasing; during 2001–2010, there was an 11.0% year-on-year increase in Hif and a 7.4% increase in Hie. In 2009–2010, Hif incidence was 0.090/100,000 persons and Hie incidence 0.030/100,000, with higher rates among infants and older adults. Hie had a more severe clinical course; although outcome at 6 months was comparable for the 2 serotypes, case-fatality rate within 7 days of diagnosis was higher for Hie, even after adjustment for age and comorbidities. Multilocus sequence typing revealed a single major circulating clone for both Hif (sequence type 124; 89/99 isolates, 90%) and Hie (sequence type 18; 21/33, 64%), but no association between type and clinical disease or outcome was found.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherU.S. Department of Health and Human Services
dc.relation.ispartofpagefrom725
dc.relation.ispartofpageto732
dc.relation.ispartofissue5
dc.relation.ispartofjournalEmerging Infectious Diseases
dc.relation.ispartofvolume18
dc.subject.fieldofresearchMedical Microbiology not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110899
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1108
dc.subject.fieldofresearchcode1117
dc.titleInvasive Haemophilus influenzae serotype e and f disease, England and Wales
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2012 Centers for Disease Control and Prevention. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorSlack, Mary P.


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