Show simple item record

dc.contributor.authorFlasche, S
dc.contributor.authorSlack, M
dc.contributor.authorMiller, E
dc.date.accessioned2018-05-08T03:09:41Z
dc.date.available2018-05-08T03:09:41Z
dc.date.issued2011
dc.identifier.issn1560-7917
dc.identifier.doi10.2807/ese.16.20.19868-en
dc.identifier.urihttp://hdl.handle.net/10072/172045
dc.description.abstractA pneumococcal conjugate vaccine (PCV7) was introduced into the United Kingdom's childhood immunisation schedule in September 2006. Evaluation of its impact on the incidence of invasive pneumococcal disease (IPD) as assessed by routine reports of laboratory-confirmed cases should take into account possible long-term trends due to factors like changes in case ascertainment. To this end, we compared pre-PCV7 trends in reported IPD incidence in England and Wales identified by blood culture with those for two other bacteraemias, Escherichia coli and non -pyogenic streptococci, for which there has not been any public health intervention. While no trend was detected in the age group 65 years and older, there was an annual increase of 3% and 11% in those aged under five years and between five and 64 years, respectively, which was similar for IPD and the other two pathogens. After PCV7 introduction, a continuing trend was only found for non-pyogenic streptococci in under five year-olds. These trends in the incidence for bacteraemias for which there has been no intervention could suggest that there have been changes in case ascertainment because of increased reporting or blood culturing. Accounting for them will improve the evaluation of the impact of PCV7 on IPD.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCentre Europeen pour la Surveillance Epidemiologique du SIDA
dc.relation.ispartofpagefrom19868-1
dc.relation.ispartofpageto19868-6
dc.relation.ispartofissue20
dc.relation.ispartofjournalEurosurveillance (Online)
dc.relation.ispartofvolume16
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchOther health sciences
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode4299
dc.titleLong term trends introduce a potential bias when evaluating the impact of the pneumococcal conjugate vaccination programme in England and Wales
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2011 European Centre for Disease Prevention and Control (ECDC). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorSlack, Mary P.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record