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dc.contributor.authorBlyth, Christopher C
dc.contributor.authorJacoby, Peter
dc.contributor.authorEffler, Paul V
dc.contributor.authorKelly, Heath
dc.contributor.authorSmith, David W
dc.contributor.authorBorland, Meredith L
dc.contributor.authorWillis, Gabriela A
dc.contributor.authorLevy, Avram
dc.contributor.authorKeil, Anthony D
dc.contributor.authorRichmond, Peter C
dc.date.accessioned2018-12-03T03:26:09Z
dc.date.available2018-12-03T03:26:09Z
dc.date.issued2016
dc.identifier.issn0891-3668
dc.identifier.doi10.1097/INF.0000000000000999
dc.identifier.urihttp://hdl.handle.net/10072/172125
dc.description.abstractBackground: Data demonstrating the effectiveness of inactivated trivalent influenza vaccine (TIV) for children at increased risk of severe disease are limited. Our objective was to determine the effectiveness of TIV in children with risk factors for severe disease and to compare vaccine uptake, parental attitudes and prescriber recommendations in children with and without risk factors for severe disease. Methods: Children aged 6–59 months presenting for emergency care (2008 to 2014) with an influenza-like illness were eligible. Influenza polymerase chain reaction/culture was performed on nasopharyngeal samples. Vaccination status was confirmed via the national register and/or vaccine providers. The test-negative design was used to estimate vaccine effectiveness (VE). Risk factors, parental attitudes and prescriber recommendations were assessed by parental questionnaire. Results: Two thousand seven hundred twenty-three children were recruited. Risk factors for severe disease included comorbid medical conditions (11.6%), preterm birth (13.0%) and indigeneity (5.0%). Influenza was identified in 546 (20.1%) participants. Overall VE (2008 and 2010 to 2014) was 70.0% (95% confidence interval: 47.7 to 82.9); VE for children with medical comorbidities, children born preterm and children <2 years were 82.5% (14.6 to 96.4), 79.2% (10.9 to 95.1) and 84.7% (49.6 to 95.3), respectively. After adverse events in 2010, the number of children fully vaccinated with TIV declined significantly. This included children with and without risk factors for severe disease. Attitudes were similar in parents of children with and without risk factors for severe disease. Conclusions: VE for TIV in young children with and without risk factors for severe disease was ≥70%. Despite this, participation in the preschool influenza vaccination program remains low with parents and prescribers unconvinced of the benefits and safety of TIV.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofpagefrom309
dc.relation.ispartofpageto315
dc.relation.ispartofissue3
dc.relation.ispartofjournalPediatric Infectious Disease Journal
dc.relation.ispartofvolume35
dc.subject.fieldofresearchMedical Microbiology not elsewhere classified
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110899
dc.subject.fieldofresearchcode1114
dc.subject.fieldofresearchcode1117
dc.titleInfluenza vaccine effectiveness and uptake in children at risk of severe disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorVan Buynder, Paul G.


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