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dc.contributor.authorSmith-Vaughan, Heidi C
dc.contributor.authorBeissbarth, Jemima
dc.contributor.authorBowman, Jacinta
dc.contributor.authorHare, Kim M
dc.contributor.authorPrice, Erin P
dc.contributor.authorPickering, Janessa
dc.contributor.authorLehmann, Deborah
dc.contributor.authorChang, Anne B
dc.contributor.authorMorris, Peter S
dc.contributor.authorMarsh, Robyn L
dc.contributor.authorLeach, Amanda J
dc.date.accessioned2018-08-30T12:30:42Z
dc.date.available2018-08-30T12:30:42Z
dc.date.issued2016
dc.identifier.issn2200-6133
dc.identifier.doi10.1186/s41479-016-0013-y
dc.identifier.urihttp://hdl.handle.net/10072/172146
dc.description.abstractNon-typeable Haemophilus influenzae (NTHi)-associated ear and respiratory diseases (including pneumonia) represent a major health burden in many parts of the world. NTHi strains retrieved from the upper airways commonly reflect those found in the lower airways. Despite growing genomic and genotyping data on NTHi, there remains a limited understanding of global and regional NTHi population structures. The aim of this study was to determine whether nasopharyngeal carriage in four Australian paediatric groups at varying risk of NTHi colonisation was dominated by the same NTHi genotypes. Genotyping data generated by PCR-ribotyping were evaluated for 3070 NTHi isolates colonising the nasopharynges of Aboriginal and non-Aboriginal children enrolled in four longitudinal studies in three separate urban and remote regions of Australia. Several NTHi PCR-ribotypes dominated in nasopharyngeal carriage, irrespective of study setting. Principal coordinates analysis confirmed a cluster of common PCR-ribotypes among all cohorts. In conclusion, we identified dominant PCR-ribotypes common to geographically disparate Australian paediatric populations. Future genomic analyses will shed further light on the precise factors underlying the dominance of certain NTHi strains in nasopharyngeal carriage.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofpagefrom13-1
dc.relation.ispartofpageto13-6
dc.relation.ispartofjournalPneumonia
dc.relation.ispartofvolume8
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1199
dc.titleGeographic consistency in dominant, non-typeable Haemophilus influenzae genotypes colonising four distinct Australian paediatric groups: a cohort study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Medicine
gro.rights.copyright© The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorSmith-Vaughan, Heidi


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