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  • A time transect of exomes from a Native American population before and after European contact

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    Author(s)
    Lindo, John
    Huerta-Sanchez, Emilia
    Nakagome, Shigeki
    Rasmussen, Morten
    Petzelt, Barbara
    Mitchell, Joycelynn
    Cybulski, Jerome S.
    Willerslev, Eske
    DeGiorgio, Michael
    Malhi, Ripan S.
    Griffith University Author(s)
    Willerslev, Eske
    Year published
    2016
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    Abstract
    A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed to this phenomenon, here we analyse 50 exomes of a continuous population from the Northwest Coast of North America, dating from before and after European contact. We model the population collapse after European contact, inferring a 57% reduction in effective population size. We also identify signatures of positive selection on immune-related genes in the ancient but not the modern group, with the strongest signal ...
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    A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed to this phenomenon, here we analyse 50 exomes of a continuous population from the Northwest Coast of North America, dating from before and after European contact. We model the population collapse after European contact, inferring a 57% reduction in effective population size. We also identify signatures of positive selection on immune-related genes in the ancient but not the modern group, with the strongest signal deriving from the human leucocyte antigen (HLA) gene HLA-DQA1. The modern individuals show a marked frequency decrease in the same alleles, likely due to the environmental change associated with European colonization, whereby negative selection may have acted on the same gene after contact. The evident shift in selection pressures correlates to the regional European-borne epidemics of the 1800s.
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    Journal Title
    Nature Communications
    Volume
    7
    DOI
    https://doi.org/10.1038/ncomms13175
    Copyright Statement
    © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
    Subject
    Population, Ecological and Evolutionary Genetics
    Publication URI
    http://hdl.handle.net/10072/172152
    Collection
    • Journal articles

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    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander