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  • Ancient genomics

    Author(s)
    Der Sarkissian, Clio
    Allentoft, Morten Erik
    Avila-Arcos, Maria C.
    Barnett, Ross
    Campos, Paula F.
    Cappellini, Enrico
    Ermini, Luca
    Fernandez, Ruth
    da Fonseca, Rute R.
    Ginolhac, Aurelien
    Hansen, Anders Johannes
    Jonsson, Hakon
    Korneliussen, Thorfinn S.
    Margaryan, Ashot
    Martin, Michael D.
    Moreno-Mayar, J. Víctor
    Raghavan, Maanasa
    Rasmussen, Morten
    Velasco, Marcela Sandoval
    Schroeder, Hannes
    Schubert, Mikkel
    Seguin-Orlando, Andaine
    Wales, Nathan A.
    Gilbert, M. Thomas P.
    Willerslev, Eske
    Orlando, Ludovic
    Griffith University Author(s)
    Willerslev, Eske
    Year published
    2015
    Metadata
    Show full item record
    Abstract
    The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of ...
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    The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.
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    Journal Title
    Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
    Volume
    370
    Issue
    1660
    DOI
    https://doi.org/10.1098/rstb.2013.0387
    Subject
    Genomics
    Biological Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/172184
    Collection
    • Journal articles

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