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dc.contributor.authorDer Sarkissian, Clio
dc.contributor.authorAllentoft, Morten Erik
dc.contributor.authorAvila-Arcos, Maria C.
dc.contributor.authorBarnett, Ross
dc.contributor.authorCampos, Paula F.
dc.contributor.authorCappellini, Enrico
dc.contributor.authorErmini, Luca
dc.contributor.authorFernandez, Ruth
dc.contributor.authorda Fonseca, Rute R.
dc.contributor.authorGinolhac, Aurelien
dc.contributor.authorHansen, Anders Johannes
dc.contributor.authorJonsson, Hakon
dc.contributor.authorKorneliussen, Thorfinn S.
dc.contributor.authorMargaryan, Ashot
dc.contributor.authorMartin, Michael D.
dc.contributor.authorMoreno-Mayar, J. Víctor
dc.contributor.authorRaghavan, Maanasa
dc.contributor.authorRasmussen, Morten
dc.contributor.authorVelasco, Marcela Sandoval
dc.contributor.authorSchroeder, Hannes
dc.contributor.authorSchubert, Mikkel
dc.contributor.authorSeguin-Orlando, Andaine
dc.contributor.authorWales, Nathan A.
dc.contributor.authorGilbert, M. Thomas P.
dc.contributor.authorWillerslev, Eske
dc.contributor.authorOrlando, Ludovic
dc.date.accessioned2017-11-30T03:22:13Z
dc.date.available2017-11-30T03:22:13Z
dc.date.issued2015
dc.identifier.issn0962-8436
dc.identifier.doi10.1098/rstb.2013.0387
dc.identifier.urihttp://hdl.handle.net/10072/172184
dc.description.abstractThe past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society Publishing
dc.relation.ispartofpagefrom20130387-1
dc.relation.ispartofpageto20130387-12
dc.relation.ispartofissue1660
dc.relation.ispartofjournalPhilosophical Transactions of the Royal Society of London. Series B: Biological Sciences
dc.relation.ispartofvolume370
dc.subject.fieldofresearchGenomics
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode060408
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleAncient genomics
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWillerslev, Eske


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