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dc.contributor.authorOrlando, Ludovic
dc.contributor.authorGilbert, M. Thomas P.
dc.contributor.authorWillerslev, Eske
dc.date.accessioned2017-11-30T05:08:03Z
dc.date.available2017-11-30T05:08:03Z
dc.date.issued2015
dc.identifier.issn1471-0056
dc.identifier.doi10.1038/nrg3935
dc.identifier.urihttp://hdl.handle.net/10072/172186
dc.description.abstractResearch involving ancient DNA (aDNA) has experienced a true technological revolution in recent years through advances in the recovery of aDNA and, particularly, through applications of high-throughput sequencing. Formerly restricted to the analysis of only limited amounts of genetic information, aDNA studies have now progressed to whole-genome sequencing for an increasing number of ancient individuals and extinct species, as well as to epigenomic characterization. Such advances have enabled the sequencing of specimens of up to 1 million years old, which, owing to their extensive DNA damage and contamination, were previously not amenable to genetic analyses. In this Review, we discuss these varied technical challenges and solutions for sequencing ancient genomes and epigenomes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom395
dc.relation.ispartofpageto408
dc.relation.ispartofissue7
dc.relation.ispartofjournalNature Reviews: Genetics
dc.relation.ispartofvolume16
dc.subject.fieldofresearchPopulation, Ecological and Evolutionary Genetics
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchcode060411
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0607
dc.titleReconstructing ancient genomes and epigenomes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWillerslev, Eske


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