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dc.contributor.authorMourier, Tobias
dc.contributor.authorNielsen, Lars Peter
dc.contributor.authorHansen, Anders Johannes
dc.contributor.authorWillerslev, Eske
dc.date.accessioned2017-11-30T06:19:48Z
dc.date.available2017-11-30T06:19:48Z
dc.date.issued2014
dc.identifier.issn1664-8021
dc.identifier.doi10.3389/fgene.2014.00156
dc.identifier.urihttp://hdl.handle.net/10072/172201
dc.description.abstractTransposable elements (TEs) are ubiquitous in eukaryotic genomes. Barbara McClintock’s famous notion of TEs acting as controlling elements modifying the genetic response of an organism upon exposure to stressful environments has since been solidly supported in a series of model organisms. This requires the TE activity response to possess an element of specificity and be targeted toward certain parts of the genome. We propose that a similar TE response is present in human cells, and that this stress response may drive the onset of human cancers. As such, TE-driven cancers may be viewed as an evolutionary by-product of organisms’ abilities to genetically adapt to environmental stress.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofpagefrom156-1
dc.relation.ispartofpageto156-8
dc.relation.ispartofissueMAY
dc.relation.ispartofjournalFrontiers in Genetics
dc.relation.ispartofvolume5
dc.subject.fieldofresearchGenetics not elsewhere classified
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchLaw
dc.subject.fieldofresearchcode060499
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1801
dc.titleTransposable elements in cancer as a by-product of stress-induced evolvability
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2014 Mourier, Nielsen, Hansen and Willerslev. This is an open-access arti-cle distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorWillerslev, Eske


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