dc.contributor.author | Mourier, Tobias | |
dc.contributor.author | Nielsen, Lars Peter | |
dc.contributor.author | Hansen, Anders Johannes | |
dc.contributor.author | Willerslev, Eske | |
dc.date.accessioned | 2017-11-30T06:19:48Z | |
dc.date.available | 2017-11-30T06:19:48Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1664-8021 | |
dc.identifier.doi | 10.3389/fgene.2014.00156 | |
dc.identifier.uri | http://hdl.handle.net/10072/172201 | |
dc.description.abstract | Transposable elements (TEs) are ubiquitous in eukaryotic genomes. Barbara McClintock’s famous notion of TEs acting as controlling elements modifying the genetic response of an organism upon exposure to stressful environments has since been solidly supported in a series of model organisms. This requires the TE activity response to possess an element of specificity and be targeted toward certain parts of the genome. We propose that a similar TE response is present in human cells, and that this stress response may drive the onset of human cancers. As such, TE-driven cancers may be viewed as an evolutionary by-product of organisms’ abilities to genetically adapt to environmental stress. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Frontiers Research Foundation | |
dc.relation.ispartofpagefrom | 156-1 | |
dc.relation.ispartofpageto | 156-8 | |
dc.relation.ispartofissue | MAY | |
dc.relation.ispartofjournal | Frontiers in Genetics | |
dc.relation.ispartofvolume | 5 | |
dc.subject.fieldofresearch | Genetics not elsewhere classified | |
dc.subject.fieldofresearch | Genetics | |
dc.subject.fieldofresearch | Clinical Sciences | |
dc.subject.fieldofresearch | Law | |
dc.subject.fieldofresearchcode | 060499 | |
dc.subject.fieldofresearchcode | 0604 | |
dc.subject.fieldofresearchcode | 1103 | |
dc.subject.fieldofresearchcode | 1801 | |
dc.title | Transposable elements in cancer as a by-product of stress-induced evolvability | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © 2014 Mourier, Nielsen, Hansen and Willerslev. This is an open-access arti-cle distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Willerslev, Eske | |