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dc.contributor.authorOlalde, Inigo
dc.contributor.authorAllentoft, Morten Erik
dc.contributor.authorSanchez-Quinto, Federico
dc.contributor.authorSantpere, Gabriel
dc.contributor.authorChiang, Charleston W. K.
dc.contributor.authorDeGiorgio, Michael
dc.contributor.authorPrado-Martinez, Javier
dc.contributor.authorRodriguez, Juan Antonio
dc.contributor.authorRasmussen, Simon
dc.contributor.authorQuilez, Javier
dc.contributor.authorRamirez, Oscar
dc.contributor.authorMarigorta, Urko M.
dc.contributor.authorFernandez-Callejo, Marcos
dc.contributor.authorPrada, Maria Encina
dc.contributor.authorEncinas, Julio Manuel Vidal
dc.contributor.authorNielsen, Rasmus
dc.contributor.authorNetea, Mihai G.
dc.contributor.authorNovembre, John
dc.contributor.authorSturm, Richard A.
dc.contributor.authorSabeti, Pardis
dc.contributor.authorMarques-Bonet, Tomas
dc.contributor.authorNavarro, Arcadi
dc.contributor.authorWillerslev, Eske
dc.contributor.authorLalueza-Fox, Carles
dc.description.abstractAncient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe1,2,3. The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet4. However, the limited data available from earlier hunter-gatherers preclude an understanding of the selective processes associated with this crucial transition to agriculture in recent human evolution. Here we sequence an approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, to retrieve a complete pre-agricultural European human genome. Analysis of this genome in the context of other ancient samples suggests the existence of a common ancient genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic. The La Braña individual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. Moreover, we provide evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.
dc.publisherNature Publishing
dc.subject.fieldofresearchPopulation, Ecological and Evolutionary Genetics
dc.titleDerived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWillerslev, Eske

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