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dc.contributor.authorRaghavan, Maanasa
dc.contributor.authorSkoglund, Pontus
dc.contributor.authorGraf, Kelly E.
dc.contributor.authorMetspalu, Mait
dc.contributor.authorAlbrechtsen, Anders
dc.contributor.authorMoltke, Ida
dc.contributor.authorRasmussen, Simon
dc.contributor.authorStafford Jr, Thomas W.
dc.contributor.authorOrlando, Ludovic
dc.contributor.authorMetspalu, Ene
dc.contributor.authorKarmin, Monika
dc.contributor.authorTambets, Kristiina
dc.contributor.authorRootsi, Siiri
dc.contributor.authorMagi, Reedik
dc.contributor.authorCampos, Paula F.
dc.contributor.authorBalanovska, Elena
dc.contributor.authorBalanovsky, Oleg
dc.contributor.authorKhusnutdinova, Elza
dc.contributor.authorLitvinov, Sergei
dc.contributor.authorOsipova, Ludmila P.
dc.contributor.authorFedorova, Sardana A.
dc.contributor.authorVoevoda, Mikhail I.
dc.contributor.authorDeGiorgio, Michael
dc.contributor.authorSicheritz-Ponten, Thomas
dc.contributor.authorBrunak, Soren
dc.contributor.authorDemeshchenko, Svetlana
dc.contributor.authorKivisild, Toomas
dc.contributor.authorVillems, Richard
dc.contributor.authorWillerslev, Eske
dc.contributor.authoret al.
dc.date.accessioned2017-12-08T06:13:08Z
dc.date.available2017-12-08T06:13:08Z
dc.date.issued2014
dc.identifier.issn0028-0836
dc.identifier.doi10.1038/nature12736
dc.identifier.urihttp://hdl.handle.net/10072/172211
dc.description.abstractThe origins of the First Americans remain contentious. Although Native Americans seem to be genetically most closely related to east Asians1,2,3, there is no consensus with regard to which specific Old World populations they are closest to4,5,6,7,8. Here we sequence the draft genome of an approximately 24,000-year-old individual (MA-1), from Mal’ta in south-central Siberia9, to an average depth of 1×. To our knowledge this is the oldest anatomically modern human genome reported to date. The MA-1 mitochondrial genome belongs to haplogroup U, which has also been found at high frequency among Upper Palaeolithic and Mesolithic European hunter-gatherers10,11,12, and the Y chromosome of MA-1 is basal to modern-day western Eurasians and near the root of most Native American lineages5. Similarly, we find autosomal evidence that MA-1 is basal to modern-day western Eurasians and genetically closely related to modern-day Native Americans, with no close affinity to east Asians. This suggests that populations related to contemporary western Eurasians had a more north-easterly distribution 24,000 years ago than commonly thought. Furthermore, we estimate that 14 to 38% of Native American ancestry may originate through gene flow from this ancient population. This is likely to have occurred after the divergence of Native American ancestors from east Asian ancestors, but before the diversification of Native American populations in the New World. Gene flow from the MA-1 lineage into Native American ancestors could explain why several crania from the First Americans have been reported as bearing morphological characteristics that do not resemble those of east Asians2,13. Sequencing of another south-central Siberian, Afontova Gora-2 dating to approximately 17,000 years ago14, revealed similar autosomal genetic signatures as MA-1, suggesting that the region was continuously occupied by humans throughout the Last Glacial Maximum. Our findings reveal that western Eurasian genetic signatures in modern-day Native Americans derive not only from post-Columbian admixture, as commonly thought, but also from a mixed ancestry of the First Americans.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherNature Publishing
dc.relation.ispartofpagefrom87
dc.relation.ispartofpageto91
dc.relation.ispartofissue7481
dc.relation.ispartofjournalNature
dc.relation.ispartofvolume505
dc.subject.fieldofresearchPopulation, Ecological and Evolutionary Genetics
dc.subject.fieldofresearchcode060411
dc.titleUpper palaeolithic Siberian genome reveals dual ancestry of native Americans
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWillerslev, Eske


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