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dc.contributor.authorWarinner, Christina
dc.contributor.authorRodrigues, Joao F. Matias
dc.contributor.authorVyas, Rounak
dc.contributor.authorTrachsel, Christian
dc.contributor.authorShved, Natallia
dc.contributor.authorGrossmann, Jonas
dc.contributor.authorRadini, Anita
dc.contributor.authorHancock, Y.
dc.contributor.authorTito, Raul Y.
dc.contributor.authorFiddyment, Sarah
dc.contributor.authorSpeller, Camilla
dc.contributor.authorHendy, Jessica
dc.contributor.authorCharlton, Sophy
dc.contributor.authorLuder, Hans Ulrich
dc.contributor.authorSalazar-Garcia, Domingo C.
dc.contributor.authorEppler, Elisabeth
dc.contributor.authorSeiler, Roger
dc.contributor.authorHansen, Lars H.
dc.contributor.authorCastruita, Jose Alfredo Samaniego
dc.contributor.authorBarkow-Oesterreicher, Simon
dc.contributor.authorTeoh, Kai Yik
dc.contributor.authorKelstrup, Christian D.
dc.contributor.authorOlsen, Jesper V.
dc.contributor.authorNanni, Paolo
dc.contributor.authorKawai, Toshihisa
dc.contributor.authorWillerslev, Eske
dc.contributor.authorvon Mering, Christian
dc.contributor.authorLewis Jr, Cecil M.
dc.contributor.authorCollins, Matthew J.
dc.contributor.authoret al.
dc.description.abstractCalcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human–associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.
dc.publisherNature Publishing Group
dc.relation.ispartofjournalNature Genetics
dc.subject.fieldofresearchAnthropological Genetics
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.titlePathogens and host immunity in the ancient human oral cavity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWillerslev, Eske

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