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dc.contributor.authorWarinner, Christina
dc.contributor.authorRodrigues, Joao F. Matias
dc.contributor.authorVyas, Rounak
dc.contributor.authorTrachsel, Christian
dc.contributor.authorShved, Natallia
dc.contributor.authorGrossmann, Jonas
dc.contributor.authorRadini, Anita
dc.contributor.authorHancock, Y.
dc.contributor.authorTito, Raul Y.
dc.contributor.authorFiddyment, Sarah
dc.contributor.authorSpeller, Camilla
dc.contributor.authorHendy, Jessica
dc.contributor.authorCharlton, Sophy
dc.contributor.authorLuder, Hans Ulrich
dc.contributor.authorSalazar-Garcia, Domingo C.
dc.contributor.authorEppler, Elisabeth
dc.contributor.authorSeiler, Roger
dc.contributor.authorHansen, Lars H.
dc.contributor.authorCastruita, Jose Alfredo Samaniego
dc.contributor.authorBarkow-Oesterreicher, Simon
dc.contributor.authorTeoh, Kai Yik
dc.contributor.authorKelstrup, Christian D.
dc.contributor.authorOlsen, Jesper V.
dc.contributor.authorNanni, Paolo
dc.contributor.authorKawai, Toshihisa
dc.contributor.authorWillerslev, Eske
dc.contributor.authorvon Mering, Christian
dc.contributor.authorLewis Jr, Cecil M.
dc.contributor.authorCollins, Matthew J.
dc.contributor.authoret al.
dc.date.accessioned2017-12-08T06:11:27Z
dc.date.available2017-12-08T06:11:27Z
dc.date.issued2014
dc.identifier.issn1061-4036
dc.identifier.doi10.1038/ng.2906
dc.identifier.urihttp://hdl.handle.net/10072/172213
dc.description.abstractCalcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human–associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom336
dc.relation.ispartofpageto344
dc.relation.ispartofissue4
dc.relation.ispartofjournalNature Genetics
dc.relation.ispartofvolume46
dc.subject.fieldofresearchAnthropological Genetics
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode060401
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titlePathogens and host immunity in the ancient human oral cavity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWillerslev, Eske


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