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dc.contributor.authorKaczmarek, Marlena C
dc.contributor.authorWare, Robert S
dc.contributor.authorMcEniery, Julie A
dc.contributor.authorCoulthard, Mark G
dc.contributor.authorLambert, Stephen B
dc.date.accessioned2017-11-15T06:15:30Z
dc.date.available2017-11-15T06:15:30Z
dc.date.issued2016
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2015-010386
dc.identifier.urihttp://hdl.handle.net/10072/172239
dc.description.abstractObjective: To review the epidemiology of pertussis-related intensive care unit (ICU) admissions across Australia, over a 17-year period. Design :Retrospective descriptive study. Setting: Australian ICUs contributing data to the Australian and New Zealand Paediatric Intensive Care (ANZPIC) Registry. The number of contributing ICUs increased over the study period, from 8 specialist paediatric ICUs in 1997 to 8 specialist paediatric and 13 general ICUs in 2013. Participants: All paediatric (<16 years) ICU admissions, coded as pertussis-related, between 1 January 1997 and 31 December 2013. Results: A total of 373 pertussis-coded ICU admissions were identified in the ANZPIC Registry over the study period. Of these cases, 52.8% occurred during the 4 years of the recent Australian epidemic (2009–2012). ICU admissions were most likely to occur in infants aged younger than 6 weeks (41.8%, n=156) and aged 6 weeks to 4 months (42.9%, n=160). The median length of stay for pertussis-related ICU admissions was 3.6 days, with 77.5% of cases staying in ICU for <7 days. Approximately half of all admissions (54.8%) required some form of respiratory support, with 32.7% requiring invasive respiratory support. Over the study period, 23 deaths were recorded (6.2% of pertussis-related ICU admissions), of which 20 (87.0%) were infants <4 months old. Conclusions: Pertussis-related ICU admissions occur primarily in infants too young to be fully protected from active immunisation. More needs to be done to protect these high-risk infants, such as maternal immunisation.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.ispartofpagefrom10386-1
dc.relation.ispartofpageto10386-8
dc.relation.ispartofissue4
dc.relation.ispartofjournalBMJ Open
dc.relation.ispartofvolume6
dc.subject.fieldofresearchEpidemiology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode111706
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1199
dc.titleEpidemiology of pertussis-related paediatric intensive care unit (ICU) admissions in Australia, 1997-2013: An observational study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyrightThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
gro.hasfulltextFull Text
gro.griffith.authorWare, Robert
gro.griffith.authorLambert, Stephen B.


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