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dc.contributor.authorJensen, DE
dc.contributor.authorNguo, K
dc.contributor.authorBaxter, KA
dc.contributor.authorCardinal, JW
dc.contributor.authorKing, NA
dc.contributor.authorWare, RS
dc.contributor.authorTruby, H
dc.contributor.authorBatch, JA
dc.date.accessioned2017-11-15T04:16:26Z
dc.date.available2017-11-15T04:16:26Z
dc.date.issued2015
dc.identifier.issn2047-6310
dc.identifier.doi10.1111/ijpo.275
dc.identifier.urihttp://hdl.handle.net/10072/172264
dc.description.abstractBackground: Gut hormones change with weight loss in adults but are not well studied in obese youth. Objective: The primary aim was to evaluate how gut hormones and subjective appetite measure change with dietary weight loss in obese adolescents. Methods: Participants were a subset of those taking part in the ‘Eat Smart Study’. They were aged 10–17 years with body mass index (BMI) > 90th centile and were randomized to one of three groups: wait-listed control, structured reduced carbohydrate or structured low-fat dietary intervention for 12 weeks. Outcomes were fasting glucose, insulin, leptin, adiponectin, total amylin, acylated ghrelin, active glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide (GIP), pancreatic polypeptide (PP) and total peptide tyrosine-tyrosine. Pre- and postprandial subjective sensations of appetite were assessed using visual analogue scales. Results: Of 87 ‘Eat Smart’ participants, 74 participated in this sub-study. The mean (standard deviation) BMI z-score was 2.1 (0.4) in the intervention groups at week 12 compared with 2.2 (0.4) in the control group. Fasting insulin (P = 0.05) and leptin (P = 0.03) levels decreased, while adiponectin levels increased (P = 0.05) in the intervention groups compared with control. The intervention groups were not significantly different from each other. A decrease in BMI z-score at week 12 was associated with decreased fasting insulin (P < 0.001), homeostatic model of assessment-insulin resistance (P < 0.001), leptin (P < 0.001), total amylin (P = 0.03), GIP (P = 0.01), PP (P = 0.02) and increased adiponectin (P < 0.001). There was no significant difference in appetite sensations. Conclusions: Modest weight loss in obese adolescents leads to changes in some adipokines and gut hormones that may favour weight regain.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.relation.ispartofpagefrom380
dc.relation.ispartofpageto387
dc.relation.ispartofissue5
dc.relation.ispartofjournalPediatric Obesity
dc.relation.ispartofvolume10
dc.subject.fieldofresearchNutrition and Dietetics not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode111199
dc.subject.fieldofresearchcode11
dc.titleFasting gut hormone levels change with modest weight loss in obese adolescents
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWare, Robert


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