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  • Malnutrition: A risk factor for severe respiratory syncytial virus infection and hospitalization

    Author(s)
    Paynter, Stuart
    Ware, Robert S
    Lucero, Marilla G
    Tallo, Veronica
    Nohynek, Hannah
    Weinstein, Philip
    Williams, Gail
    Sly, Peter D
    Simoes, Eric AF
    Griffith University Author(s)
    Ware, Robert
    Year published
    2014
    Metadata
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    Abstract
    Background: Longitudinal information examining the effect of poor infant growth on respiratory syncytial virus (RSV) severity is limited. Children hospitalized with RSV lower respiratory infection represent those at the severe end of the disease spectrum. Methods: We followed up a cohort of 12,191 infants enrolled in a previous pneumococcal vaccine trial in Bohol, Philippines. Exposure measures were weight for age z-score at the first vaccination visit (median age 1.8 months) as well as the growth (the difference in weight for age z-score) between the first and third vaccination visits. The outcome was hospitalization with ...
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    Background: Longitudinal information examining the effect of poor infant growth on respiratory syncytial virus (RSV) severity is limited. Children hospitalized with RSV lower respiratory infection represent those at the severe end of the disease spectrum. Methods: We followed up a cohort of 12,191 infants enrolled in a previous pneumococcal vaccine trial in Bohol, Philippines. Exposure measures were weight for age z-score at the first vaccination visit (median age 1.8 months) as well as the growth (the difference in weight for age z-score) between the first and third vaccination visits. The outcome was hospitalization with RSV lower respiratory infection. Results: Children with a weight for age z-score ≤ −2 at their first vaccination visit had the highest rate of hospitalization with RSV lower respiratory infection, but this association was only evident in children whose mothers had >10 years of education (hazard ratio: 3.38; 95% confidence interval: 1.63–6.98). Children who had lower than median growth between their first and third vaccinations had a higher rate of RSV-associated hospitalization than those with growth above the median (hazard ratio: 1.34; 95% confidence interval: 1.02–1.76). Conclusions: Poor infant growth increases the risk for severe RSV infection leading to hospitalization.
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    Journal Title
    Pediatric Infectious Disease Journal
    Volume
    33
    Issue
    3
    DOI
    https://doi.org/10.1097/INF.0000000000000096
    Subject
    Reproductive medicine not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/172349
    Collection
    • Journal articles

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