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dc.contributor.authorPaynter, Stuart
dc.contributor.authorWare, Robert S
dc.contributor.authorLucero, Marilla G
dc.contributor.authorTallo, Veronica
dc.contributor.authorNohynek, Hannah
dc.contributor.authorWeinstein, Philip
dc.contributor.authorWilliams, Gail
dc.contributor.authorSly, Peter D
dc.contributor.authorSimoes, Eric AF
dc.date.accessioned2017-10-23T05:00:06Z
dc.date.available2017-10-23T05:00:06Z
dc.date.issued2014
dc.identifier.issn0891-3668
dc.identifier.doi10.1097/INF.0000000000000096
dc.identifier.urihttp://hdl.handle.net/10072/172349
dc.description.abstractBackground: Longitudinal information examining the effect of poor infant growth on respiratory syncytial virus (RSV) severity is limited. Children hospitalized with RSV lower respiratory infection represent those at the severe end of the disease spectrum. Methods: We followed up a cohort of 12,191 infants enrolled in a previous pneumococcal vaccine trial in Bohol, Philippines. Exposure measures were weight for age z-score at the first vaccination visit (median age 1.8 months) as well as the growth (the difference in weight for age z-score) between the first and third vaccination visits. The outcome was hospitalization with RSV lower respiratory infection. Results: Children with a weight for age z-score ≤ −2 at their first vaccination visit had the highest rate of hospitalization with RSV lower respiratory infection, but this association was only evident in children whose mothers had >10 years of education (hazard ratio: 3.38; 95% confidence interval: 1.63–6.98). Children who had lower than median growth between their first and third vaccinations had a higher rate of RSV-associated hospitalization than those with growth above the median (hazard ratio: 1.34; 95% confidence interval: 1.02–1.76). Conclusions: Poor infant growth increases the risk for severe RSV infection leading to hospitalization.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofpagefrom267
dc.relation.ispartofpageto271
dc.relation.ispartofissue3
dc.relation.ispartofjournalPediatric Infectious Disease Journal
dc.relation.ispartofvolume33
dc.subject.fieldofresearchReproductive medicine not elsewhere classified
dc.subject.fieldofresearchcode321599
dc.titleMalnutrition: A risk factor for severe respiratory syncytial virus infection and hospitalization
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWare, Robert


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