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  • Number and order of whole cell pertussis vaccines in infancy and disease protection

    Author(s)
    Sheridan, Sarah L
    Ware, Robert S
    Grimwood, Keith
    Lambert, Stephen B
    Griffith University Author(s)
    Grimwood, Keith
    Ware, Robert
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    Due to their lower rate of adverse events, acellular pertussis vaccines (diphtheria-tetanus-acellular pertussis; DTaP) replaced whole cell vaccines (diphtheria-tetanus-whole cell pertussis; DTwP) in many developed countries during the 1990s. DTaP became available in Queensland, Australia, in 1996 and replaced DTwP for publicly funded primary course immunizations delivered at ages 2 months, 4 months, and 6 months in March 1999. This meant children born in 1998 could receive a primary course consisting of only DTwP, only DTaP, or a mixed schedule. Similar to North America,1 Australia is experiencing a sustained pertussis ...
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    Due to their lower rate of adverse events, acellular pertussis vaccines (diphtheria-tetanus-acellular pertussis; DTaP) replaced whole cell vaccines (diphtheria-tetanus-whole cell pertussis; DTwP) in many developed countries during the 1990s. DTaP became available in Queensland, Australia, in 1996 and replaced DTwP for publicly funded primary course immunizations delivered at ages 2 months, 4 months, and 6 months in March 1999. This meant children born in 1998 could receive a primary course consisting of only DTwP, only DTaP, or a mixed schedule. Similar to North America,1 Australia is experiencing a sustained pertussis epidemic,2 with the highest incidence rates in Queensland during 2011 in children aged 6 to 11 years. The recent changes in pertussis epidemiology may be related to the shift from DTwP to DTaP. To test this hypothesis, we compared pertussis reporting rates by primary course vaccination in the 1998 birth cohort.
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    Journal Title
    JAMA: The Journal of the American Medical Association
    Volume
    308
    Issue
    5
    DOI
    https://doi.org/10.1001/jama.2012.6364
    Subject
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/172367
    Collection
    • Journal articles

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