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  • Tuneable Surface Shear Forces to Physically Displace Nonspecific Molecules in Protein Biomarker Detection

    Author(s)
    Vaidyanathan, Ramanathan
    Rauf, Sakandar
    Shiddiky, Muhammad JA
    Trau, Matt
    Griffith University Author(s)
    Shiddiky, Muhammad J.
    Year published
    2014
    Metadata
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    Abstract
    We report a simple method to remove nonspecifically adsorbed species from sensor surface and also improve the detection sensitivity of the sensor using tuneable alternating current (ac) electrohydrodynamics (ac-EHD) forces. These forces generated within few nanometers of an electrode surface (i.e., double layer) engender fluid flow within a serpentine channel containing a long array of the asymmetric electrode pairs, and can easily be tuned externally by changing the frequency and amplitude of the ac-EHD field. Under the optimized experimental conditions, we achieved a 3.5-fold reduction in nonspecific adsorption of non-target ...
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    We report a simple method to remove nonspecifically adsorbed species from sensor surface and also improve the detection sensitivity of the sensor using tuneable alternating current (ac) electrohydrodynamics (ac-EHD) forces. These forces generated within few nanometers of an electrode surface (i.e., double layer) engender fluid flow within a serpentine channel containing a long array of the asymmetric electrode pairs, and can easily be tuned externally by changing the frequency and amplitude of the ac-EHD field. Under the optimized experimental conditions, we achieved a 3.5-fold reduction in nonspecific adsorption of non-target proteins with a 1000-fold enhancement in detection sensitivity of the device for the analysis of human epidermal growth factor receptor 2 (HER2) protein spiked in serum. This approach can be applicable in diverse fields including biosensors, cellular and molecular separation systems and biomedical applications to remove/reduce nonspecific adsorption of molecular and cellular species.
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    Journal Title
    Biosensors and Bioelectronics
    Volume
    61
    DOI
    https://doi.org/10.1016/j.bios.2014.03.061
    Subject
    Analytical chemistry
    Analytical chemistry not elsewhere classified
    Biomedical engineering
    Nanotechnology
    Publication URI
    http://hdl.handle.net/10072/172432
    Collection
    • Journal articles

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