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dc.contributor.authorVaidyanathan, Ramanathan
dc.contributor.authorRauf, Sakandar
dc.contributor.authorShiddiky, Muhammad JA
dc.contributor.authorTrau, Matt
dc.date.accessioned2018-02-27T03:12:32Z
dc.date.available2018-02-27T03:12:32Z
dc.date.issued2014
dc.identifier.issn0956-5663
dc.identifier.doi10.1016/j.bios.2014.03.061
dc.identifier.urihttp://hdl.handle.net/10072/172432
dc.description.abstractWe report a simple method to remove nonspecifically adsorbed species from sensor surface and also improve the detection sensitivity of the sensor using tuneable alternating current (ac) electrohydrodynamics (ac-EHD) forces. These forces generated within few nanometers of an electrode surface (i.e., double layer) engender fluid flow within a serpentine channel containing a long array of the asymmetric electrode pairs, and can easily be tuned externally by changing the frequency and amplitude of the ac-EHD field. Under the optimized experimental conditions, we achieved a 3.5-fold reduction in nonspecific adsorption of non-target proteins with a 1000-fold enhancement in detection sensitivity of the device for the analysis of human epidermal growth factor receptor 2 (HER2) protein spiked in serum. This approach can be applicable in diverse fields including biosensors, cellular and molecular separation systems and biomedical applications to remove/reduce nonspecific adsorption of molecular and cellular species.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom184
dc.relation.ispartofpageto191
dc.relation.ispartofjournalBiosensors and Bioelectronics
dc.relation.ispartofvolume61
dc.subject.fieldofresearchAnalytical chemistry
dc.subject.fieldofresearchAnalytical chemistry not elsewhere classified
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchcode3401
dc.subject.fieldofresearchcode340199
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode4018
dc.titleTuneable Surface Shear Forces to Physically Displace Nonspecific Molecules in Protein Biomarker Detection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorShiddiky, Muhammad J.


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