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dc.contributor.authorIbn Sina, Abu Ali
dc.contributor.authorHowell, Sidney
dc.contributor.authorCarrascosa, Laura G
dc.contributor.authorRauf, Sakandar
dc.contributor.authorShiddiky, Muhammad JA
dc.contributor.authorTrau, Matt
dc.date.accessioned2018-02-27T01:09:03Z
dc.date.available2018-02-27T01:09:03Z
dc.date.issued2014
dc.identifier.issn1359-7345
dc.identifier.doi10.1039/c4cc06732k
dc.identifier.urihttp://hdl.handle.net/10072/172433
dc.description.abstractWe report a simple electrochemical method referred to as “eMethylsorb” for the detection of DNA methylation. The method relies on the base dependent affinity interaction of DNA with gold. The methylation status of DNA is quantified by monitoring the electrochemical current as a function of the relative adsorption level of bisulphite treated DNA samples onto a bare gold electrode. This method can successfully distinguish methylated and unmethylated epigenotypes at single CpG resolution.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofpagefrom13153
dc.relation.ispartofpageto13156
dc.relation.ispartofissue86
dc.relation.ispartofjournalChemical Communications
dc.relation.ispartofvolume50
dc.subject.fieldofresearchAnalytical Chemistry not elsewhere classified
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchcode030199
dc.subject.fieldofresearchcode03
dc.titleeMethylsorb: Electrochemical Quantification Of DNA Methylation at CPG Resolution Using DNA–Gold Affinity Interactions
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2014 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorShiddiky, Muhammad J.


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