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  • Optical Biosensing Strategies for DNA Methylation Analysis

    Author(s)
    Islam, Md Nazmul
    Yadav, Sharda
    Hague, Md Hakimul
    Munaz, Ahmed
    Islam, Farhadul
    Al Hossain, Md Shahriar
    Gopalan, Vinod
    Lam, Alfred K
    Nam-Trung, Nguyen
    Shiddiky, Muhammad JA
    Griffith University Author(s)
    Lam, Alfred K.
    Gopalan, Vinod
    Islam, Farhad
    Nguyen, Nam-Trung
    Shiddiky, Muhammad J.
    Yadav, Sharda
    Year published
    2017
    Metadata
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    Abstract
    DNA methylation is an epigenetic modification of DNA, where a methyl group is added at the fifth carbon of the cytosine base to form 5 methyl cytosine (5mC) without altering the DNA sequences. It plays important roles in regulating many cellular processes by modulating key genes expression. Alteration in DNA methylation patterns becomes particularly important in the aetiology of different diseases including cancers. Abnormal methylation pattern could contribute to the pathogenesis of cancer either by silencing key tumor suppressor genes or by activating oncogenes. Thus, DNA methylation biosensing can help in the better ...
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    DNA methylation is an epigenetic modification of DNA, where a methyl group is added at the fifth carbon of the cytosine base to form 5 methyl cytosine (5mC) without altering the DNA sequences. It plays important roles in regulating many cellular processes by modulating key genes expression. Alteration in DNA methylation patterns becomes particularly important in the aetiology of different diseases including cancers. Abnormal methylation pattern could contribute to the pathogenesis of cancer either by silencing key tumor suppressor genes or by activating oncogenes. Thus, DNA methylation biosensing can help in the better understanding of cancer prognosis and diagnosis and aid the development of therapies. Over the last few decades, a plethora of optical detection techniques have been developed for analyzing DNA methylation using fluorescence, Raman spectroscopy, surface plasmon resonance (SPR), electrochemiluminescence and colorimetric readouts. This paper aims to comprehensively review the optical strategies for DNA methylation detection. We also present an overview of the remaining challenges of optical strategies that still need to be focused along with the lesson learnt while working with these techniques.
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    Journal Title
    Biosensors and Bioelectronics
    DOI
    https://doi.org/10.1016/j.bios.2016.10.034
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Analytical chemistry
    Analytical chemistry not elsewhere classified
    Biomedical engineering
    Nanotechnology
    Publication URI
    http://hdl.handle.net/10072/172460
    Collection
    • Journal articles

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