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dc.contributor.authorDarby, Richard A. J.
dc.contributor.authorCallaghan, Richard
dc.contributor.authorMcMahon, Roisin M.
dc.date.accessioned2018-12-07T01:02:22Z
dc.date.available2018-12-07T01:02:22Z
dc.date.issued2011
dc.identifier.issn1389-2002en_US
dc.identifier.doi10.2174/138920011798357006en_US
dc.identifier.urihttp://hdl.handle.net/10072/172516
dc.description.abstractThe multidrug resistant phenotype of cancer cells can often result from the over-production of a number of ATP binding cassette (ABC) transporters, including P-glycoprotein (P-gp). These multidrug efflux transporters expel administered anti-cancer drugs from the cancer cell, preventing sufficient intracellular drug accumulation and ultimately, drug efficacy. The co-administration of compounds that can impede the efflux of chemotherapeutic agents by these ABC transporters can concomitantly modulate various cytochrome P450 (CYP450) enzymes, consequently impacting upon anti-cancer drug metabolism. This can further result in unfavourable drug-drug interactions and altered pharmacokinetic properties of the administered anti-cancer drugs with knock-on adverse cytotoxic side effects. This review will discuss some of the P-gp inhibitors designed and employed to date, as well as expressing our views of the shortcomings of their design strategy. We present a medicinal chemists wish list for the paradigmatic P-gp inhibitor molecule and examine the possible future strategies that could be implemented to achieve its design.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherBentham Science Publishers Ltd.en_US
dc.relation.ispartofpagefrom722en_US
dc.relation.ispartofpageto731en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalCurrent Drug Metabolismen_US
dc.relation.ispartofvolume12en_US
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode111599en_US
dc.titleP-glycoprotein inhibition: The past, the present and the futureen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text


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