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dc.contributor.authorDarby, Richard AJ
dc.contributor.authorCallaghan, Richard
dc.contributor.authorMcMahon, Roisin M
dc.date.accessioned2018-12-07T01:02:22Z
dc.date.available2018-12-07T01:02:22Z
dc.date.issued2011
dc.identifier.issn1389-2002
dc.identifier.doi10.2174/138920011798357006
dc.identifier.urihttp://hdl.handle.net/10072/172516
dc.description.abstractThe multidrug resistant phenotype of cancer cells can often result from the over-production of a number of ATP binding cassette (ABC) transporters, including P-glycoprotein (P-gp). These multidrug efflux transporters expel administered anti-cancer drugs from the cancer cell, preventing sufficient intracellular drug accumulation and ultimately, drug efficacy. The co-administration of compounds that can impede the efflux of chemotherapeutic agents by these ABC transporters can concomitantly modulate various cytochrome P450 (CYP450) enzymes, consequently impacting upon anti-cancer drug metabolism. This can further result in unfavourable drug-drug interactions and altered pharmacokinetic properties of the administered anti-cancer drugs with knock-on adverse cytotoxic side effects. This review will discuss some of the P-gp inhibitors designed and employed to date, as well as expressing our views of the shortcomings of their design strategy. We present a medicinal chemists wish list for the paradigmatic P-gp inhibitor molecule and examine the possible future strategies that could be implemented to achieve its design.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherBentham Science Publishers Ltd.
dc.relation.ispartofpagefrom722
dc.relation.ispartofpageto731
dc.relation.ispartofissue8
dc.relation.ispartofjournalCurrent Drug Metabolism
dc.relation.ispartofvolume12
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classified
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchArtificial Intelligence and Image Processing
dc.subject.fieldofresearchcode111599
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode0801
dc.titleP-glycoprotein inhibition: The past, the present and the future
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorMcMahon, Roisin


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