dc.contributor.author | Mokhtarzadeh, Hossein | |
dc.contributor.author | Aw, Moom S | |
dc.contributor.author | Khalid, Kamarul A | |
dc.contributor.author | Gulati, Karan | |
dc.contributor.author | Atkins, Gerald J | |
dc.contributor.author | Findlay, David M | |
dc.contributor.author | Losic, Dusan | |
dc.contributor.author | Pivonka, Peter | |
dc.contributor.editor | Onate, E | |
dc.contributor.editor | Oliver, X | |
dc.contributor.editor | Huerta, A | |
dc.date.accessioned | 2018-02-15T05:11:55Z | |
dc.date.available | 2018-02-15T05:11:55Z | |
dc.date.issued | 2014 | |
dc.identifier.isbn | 9788494284472 | |
dc.identifier.uri | http://hdl.handle.net/10072/172746 | |
dc.description.abstract | This paper describes fully coupled advective-diffusive transport of a drug through a
trabecular bone sample in a perfused bioreactor. We used the analogy between heat transfer
and mass transfer in order to derive the effective transport properties of the porous material
such as effective diffusion coefficient and permeability. This allowed employing the heat
transfer equations in Abaqus and they were solved using the finite element (FE) method. The
average velocity was calculated using the Darcy-Brinkman-Forchheimer equation. Simulation
results suggest that effective diffusivity plays a major role in the spatio-temporal distribution
of the drug in the bone sample. Bone permeability was found less effective on manipulating
the spatial distribution of drug. The bioreactor perfusion rate played a major role in the
distribution of the drug throughout the bone sample. Increased perfusion rate leads to
clearance of the drug towards the outlet of the bioreactor. It was found that even for moderate
bioreactor perfusion rates the drug was concentrated towards the outlet, while zero
concentration of drug was observed around the inlet. The numerical simulations showed that
the essential effects of local drug release in bone can be captured using fluid flow through
porous media theory. Our simulation results revealed that drug delivery is a multi-factorial
phenomenon. Therefore, a mathematical model can enhance our understanding of this
complicated problem that is difficult to characterize using experimental techniques alone. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | International Center for Numerical Methods in Engineering | |
dc.publisher.uri | http://www.wccm-eccm-ecfd2014.org | |
dc.relation.ispartofconferencename | 11th World Congress on Computational Mechanics (WCCM) / 5th European Conference on Computational Mechanics (ECCM) / 6th European Conference on Computational Fluid Dynamics (ECFD) | |
dc.relation.ispartofconferencetitle | 11TH WORLD CONGRESS ON COMPUTATIONAL MECHANICS; 5TH EUROPEAN CONFERENCE ON COMPUTATIONAL MECHANICS; 6TH EUROPEAN CONFERENCE ON COMPUTATIONAL FLUID DYNAMICS, VOLS II - IV | |
dc.relation.ispartofdatefrom | 2014-07-20 | |
dc.relation.ispartofdateto | 2014-07-25 | |
dc.relation.ispartoflocation | Barcelona, SPAIN | |
dc.relation.ispartofpagefrom | 868 | |
dc.relation.ispartofpageto | 879 | |
dc.relation.ispartofedition | 1st | |
dc.subject.fieldofresearch | Materials engineering not elsewhere classified | |
dc.subject.fieldofresearchcode | 401699 | |
dc.title | Computational and experimental model of nano-engineered drug delivery system for trabecular bone | |
dc.type | Conference output | |
dc.type.description | E1 - Conferences | |
dc.type.code | E - Conference Publications | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Gulati, Karan | |