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dc.contributor.authorChang, Anne B
dc.contributor.authorYerkovich, Stephanie T
dc.contributor.authorGibson, Peter G
dc.contributor.authorAnderson-James, Sophie
dc.contributor.authorPetsky, Helen L
dc.contributor.authorCarroll, Melanie L
dc.contributor.authorMasters, I Brent
dc.contributor.authorMarchant, Julie M
dc.contributor.authorWurzel, Danielle
dc.contributor.authorUpham, John W
dc.date.accessioned2017-12-19T01:21:49Z
dc.date.available2017-12-19T01:21:49Z
dc.date.issued2012
dc.identifier.issn0022-3476
dc.identifier.doi10.1016/j.jpeds.2012.03.049
dc.identifier.urihttp://hdl.handle.net/10072/172800
dc.description.abstractObjective: To determine bronchoalveolar lavage (BAL) levels of 3 innate immunity components (human β-defensin-2 [hBD2], mannose-binding lectin [MBL], and surfactant protein-A [SP-A]), the relationship with airway neutrophilia and infection, and cytokine production of stimulated BAL cells in children with current protracted bacterial bronchitis (PBB), children with resolved PBB (PBB well), and controls. Study design: BAL of 102 children (mean age 2.8 years) fulfilling predefined criteria of current PBB (n = 61), PBB well (n = 20), and controls (n = 21) was cultured (quantitative bacteriology) and viruses examined by polymerase chain reaction. hBD2, MBL, and SP-A were measured, and cytokine production by lipopolysaccharide-stimulated BAL cells was determined. Results: Median hBD2 and MBL levels were significantly higher in the current PBB group (hBD2 = 164.4, IQR 0-435.5 pg/mL; MBL = 1.7, 0.4-4 ng/mL) than in the PBB well group (hBD2 = 0, IQR 0-85.2; MBL = 0.6, IQR 0.03-2.9) and controls (hBD2 = 3.6, IQR 0-126; MBL = 0.4, IQR 0.02-79). hBD2 was significantly higher in children with airway infection (n = 54; median 76.9, IQR 0-397.3) compared with those without (n = 48; 0, IQR 0-236.3), P = .04. SP-A levels and cytokine production of stimulated BAL cells were similar between groups. Conclusion: In children’s airways, hBD2, but not MBL and SP-A, relates to inflammation and infection. In children with PBB, mechanisms involving airway hBD2 and MBL are augmented. These pulmonary innate immunity components and the ability of BAL cells to respond to stimuli are unlikely to be deficient.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMosby
dc.relation.ispartofpagefrom621
dc.relation.ispartofpageto625.e1
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Pediatrics
dc.relation.ispartofvolume161
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchcode4207
dc.titlePulmonary innate immunity in children with protracted bacterial bronchitis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorPetsky, Helen


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