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dc.contributor.authorMarchant, Julie
dc.contributor.authorMasters, Ian Brent
dc.contributor.authorChampion, Anita
dc.contributor.authorPetsky, Helen
dc.contributor.authorChang, Anne B
dc.date.accessioned2017-12-19T01:28:54Z
dc.date.available2017-12-19T01:28:54Z
dc.date.issued2012
dc.identifier.issn0040-6376
dc.identifier.doi10.1136/thoraxjnl-2011-201506
dc.identifier.urihttp://hdl.handle.net/10072/172804
dc.description.abstractBackground Despite guideline recommendations, there are no published randomised controlled trial data on the efficacy of antibiotics for chronic wet cough in children. The majority of children with chronic wet cough have protracted bacterial bronchitis (PBB), a recognised condition in multiple national guidelines. The authors conducted a parallel 1:1 placebo randomised controlled trial to test the hypothesis that a 2-week course of amoxycillin clavulanate is efficacious in the treatment of children with chronic wet cough. Methods 50 children (median age 1.9 years, IQR 0.9–5.1) with chronic (>3 weeks) wet cough were randomised to 2 weeks of twice daily oral amoxycillin clavulanate (22.5 mg/kg/dose) or placebo. The primary outcome was ‘cough resolution’ defined as a >75% reduction in the validated verbal category descriptive cough score within 14 days of treatment compared with baseline scores, or cessation of cough for >3 days. In selected children, flexible bronchoscopy and bronchoalveolar lavage (BAL) were undertaken at baseline. Results Cough resolution rates (48%) were significantly higher in children who received amoxycillin clavulanate compared with those who received placebo (16%), p=0.016. The observed difference between proportions was 0.32 (95% CI 0.08 to 0.56). Post treatment, median verbal category descriptive score in the amoxycillin clavulanate group of 0.5 (IQR 0.0–2.0) was significantly lower than in the placebo group, 2.25 (IQR 1.15–2.9) (p=0.02). Pre-treatment BAL data were consistent with PBB in the majority of children, with no significant difference between groups. Conclusion A 2-week course of amoxycillin clavulanate will achieve cough resolution in a significant number of children with chronic wet cough. BAL data support the diagnosis of PBB in the majority of these children.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherB M J Group
dc.relation.ispartofpagefrom689
dc.relation.ispartofpageto693
dc.relation.ispartofissue8
dc.relation.ispartofjournalThorax
dc.relation.ispartofvolume67
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode111403
dc.subject.fieldofresearchcode1103
dc.titleRandomised controlled trial of amoxycillin clavulanate in children with chronic wet cough
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorPetsky, Helen


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