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dc.contributor.authorYerkovich, Stephanie T
dc.contributor.authorChang, Anne B
dc.contributor.authorCarroll, Melanie L
dc.contributor.authorPetsky, Helen L
dc.contributor.authorScrivener, Greta
dc.contributor.authorUpham, John W
dc.date.accessioned2017-12-19T01:23:27Z
dc.date.available2017-12-19T01:23:27Z
dc.date.issued2012
dc.identifier.issn1323-7799
dc.identifier.doi10.1111/j.1440-1843.2012.02174.x
dc.identifier.urihttp://hdl.handle.net/10072/172805
dc.description.abstractBackground and objective: The soluble receptor for advanced glycation end products (sRAGE) plays an important role in inflammation. Few studies have looked at sRAGE levels in human lungs, and there is no information in children. Therefore, this study aimed to compare bronchoalveolar lavage fluid (BALF) and plasma sRAGE concentrations in children in relation to age and inflammation. Methods: BAL was performed in 76 children, and BALF and plasma sRAGE levels were determined by enzyme-linked immunosorbent assay. Results: sRAGE levels were fourfold higher in BALF than in plasma (P < 0.001). BALF sRAGE was inversely proportional to age (r = −0.333, P = 0.008) and serum immunoglobulin A (r = −0.283, P = 0.028). Plasma sRAGE showed a positive correlation to the percentage of BAL macrophages and negative correlation to the percentage of neutrophils and lymphocytes (P < 0.05). Multivariate linear regression analysis identified that the percentage of BAL lymphocytes and neutrophils were significant independent predictors of plasma sRAGE levels, while age and the percentage of BAL macrophages independently predicted BALF sRAGE levels. Conclusions: In children, sRAGE is present at higher concentrations in the lung compared with blood. It appears that sRAGE varies with age, and hence future studies of sRAGE in paediatric lung disease require age matching. The significant relationship between sRAGE and lung inflammation warrants further research.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Asia
dc.relation.ispartofpagefrom841
dc.relation.ispartofpageto846
dc.relation.ispartofissue5
dc.relation.ispartofjournalRespirology
dc.relation.ispartofvolume17
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode111403
dc.subject.fieldofresearchcode11
dc.titleSoluble receptor for advanced glycation end products (sRAGE) is present at high concentrations in the lungs of children and varies with age and the pattern of lung inflammation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorPetsky, Helen


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