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  • Synthesis and spectroscopic characteristation of a combinatoiral library based on the fungal natural product 3-chloro-4-hydroxyphenylacetamide

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    Author(s)
    Davis, Rohan A
    Pierens, Gregory K
    Parsons, Peter G
    Griffith University Author(s)
    Davis, Rohan A.
    Year published
    2007
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    Abstract
    Parallel solution-phase chemistry has yielded a series of secondary amide analogues of the fungal natural product 3-chloro-4-hydroxyphenylacetamide. 3-Chloro-4-hydroxyphenylacetic acid was coupled to a variety of primary amines using 1-ethyl-3-(3-dimethylamino- propyl)-carbodiimide hydrochloride. The desired products were obtained in good yield and high purity following rapid silica purification. All analogues were spectroscopically characterised using NMR, UV, IR and MS data. One compound displayed moderate cytotoxicity against the human melanoma and prostate cell lines, MM96L and DU145. Copyright 頲007 John Wiley & Sons, Ltd.Parallel solution-phase chemistry has yielded a series of secondary amide analogues of the fungal natural product 3-chloro-4-hydroxyphenylacetamide. 3-Chloro-4-hydroxyphenylacetic acid was coupled to a variety of primary amines using 1-ethyl-3-(3-dimethylamino- propyl)-carbodiimide hydrochloride. The desired products were obtained in good yield and high purity following rapid silica purification. All analogues were spectroscopically characterised using NMR, UV, IR and MS data. One compound displayed moderate cytotoxicity against the human melanoma and prostate cell lines, MM96L and DU145. Copyright 頲007 John Wiley & Sons, Ltd.
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    Journal Title
    Magnetic Resonance in Chemistry
    Volume
    45
    DOI
    https://doi.org/10.1002/mrc.1984
    Copyright Statement
    © 2007 John Wiley & Sons, Ltd. This is the peer reviewed version of the following article: Synthesis and spectroscopic characteristation of a combinatoiral library based on the fungal natural product 3-chloro-4-hydroxyphenylacetamide, Magnetic Resonance in Chemistry, Vol. 45, pp. 442-445, 2007 which has been published in final form at http://dx.doi.org/10.1002/mrc.1984. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms)
    Subject
    Medicinal and biomolecular chemistry
    Physical chemistry
    Publication URI
    http://hdl.handle.net/10072/17281
    Collection
    • Journal articles

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