Endiandrin A, a Potent Glucocorticoid Receptor Binder Isolated from the Australian Plant Endiandra anthropophagorum

Bioassay-guided fractionation of the DCM extract from the roots of Endiandra anthropophagorum resulted in the isolation of a new cyclobutane lignan, endiandrin A (1), together with the known natural products nectandrin B (2) and (-)-dihydroguaiaretic acid (3). The structure of 1 was determined by extensive 1D and 2D NMR and MS data analyses. Acetylation and methylation of 1 yielded di-O-acetylendiandrin A (4) and di-O-methylendiandrin A (5), respectively. All compounds were tested in a glucocorticoid receptor binding assay and displayed IC50 values ranging from 0.9 to 35 卮Bioassay-guided fractionation of the DCM extract from the roots of Endiandra anthropophagorum resulted in the isolation of a new cyclobutane lignan, endiandrin A (1), together with the known natural products nectandrin B (2) and (-)-dihydroguaiaretic acid (3). The structure of 1 was determined by extensive 1D and 2D NMR and MS data analyses. Acetylation and methylation of 1 yielded di-O-acetylendiandrin A (4) and di-O-methylendiandrin A (5), respectively. All compounds were tested in a glucocorticoid receptor binding assay and displayed IC50 values ranging from 0.9 to 35 卮
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Journal Title

Journal of Natural Products

Volume

DOI

https://doi.org/10.1021/np070073x

Copyright Statement

This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright 2007 American Chemical Society and the American Society of Pharmacognosy after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np070073x

Subject

Chemical sciences

Biological sciences

Biomedical and clinical sciences

Traditional, complementary and integrative medicine

Publication URI

http://hdl.handle.net/10072/17282

Collection

Journal articles