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dc.contributor.authorMueller, Kathryn L
dc.contributor.authorMurray, Jeffrey C
dc.contributor.authorMichaelson, Jacob J
dc.contributor.authorChristiansen, Morten H
dc.contributor.authorReilly, Sheena
dc.contributor.authorTomblin, J Bruce
dc.date.accessioned2018-01-19T05:58:33Z
dc.date.available2018-01-19T05:58:33Z
dc.date.issued2016
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0152576
dc.identifier.urihttp://hdl.handle.net/10072/172843
dc.description.abstractMuch of our current knowledge regarding the association of FOXP2 with speech and language development comes from singleton and small family studies where a small number of rare variants have been identified. However, neither genome-wide nor gene-specific studies have provided evidence that common polymorphisms in the gene contribute to individual differences in language development in the general population. One explanation for this inconsistency is that previous studies have been limited to relatively small samples of individuals with low language abilities, using low density gene coverage. The current study examined the association between common variants in FOXP2 and a quantitative measure of language ability in a population-based cohort of European decent (n = 812). No significant associations were found for a panel of 13 SNPs that covered the coding region of FOXP2 and extended into the promoter region. Power analyses indicated we should have been able to detect a QTL variance of 0.02 for an associated allele with MAF of 0.2 or greater with 80% power. This suggests that, if a common variant associated with language ability in this gene does exist, it is likely of small effect. Our findings lead us to conclude that while genetic variants in FOXP2 may be significant for rare forms of language impairment, they do not contribute appreciably to individual variation in the normal range as found in the general population.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Sciences
dc.relation.ispartofpagefrome0152576-1
dc.relation.ispartofpagetoe0152576-17
dc.relation.ispartofissue4
dc.relation.ispartofjournalPLoS One
dc.relation.ispartofvolume11
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchcode110399
dc.titleCommon genetic variants in FOXP2 are not associated with individual differences in language development
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 Mueller et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorReilly, Sheena


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