Silver(I)-glutathione biocoordination polymer hydrogel: Effective antibacterial activity and improved cytocompatibility

Abstract

A Ag(I)–glutathione biocoordination polymer hydrogel is fabricated and further cross-linked by Ca2+ ions. Compared with commercial silver sulfadiazine cream, the cross-linked Ag(I)–glutathione hydrogel exhibits effective antibacterial activity and improved cytocompatibility, which represents the first antibacterial hydrogel based on biocoordination polymers and has potential application in the biomedical field, e.g., burn wound dressings.