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dc.contributor.authorHao, Xian
dc.contributor.authorShang, Xin
dc.contributor.authorWu, Jiazhen
dc.contributor.authorShan, Yuping
dc.contributor.authorCai, Mingjun
dc.contributor.authorJiang, Junguang
dc.contributor.authorHuang, Zhong
dc.contributor.authorTang, Zhiyong
dc.contributor.authorWang, Hongda
dc.date.accessioned2017-11-03T05:45:56Z
dc.date.available2017-11-03T05:45:56Z
dc.date.issued2011
dc.identifier.issn1613-6810
dc.identifier.doi10.1002/smll.201002020
dc.identifier.urihttp://hdl.handle.net/10072/172983
dc.description.abstractHBsAg, the surface antigen of the hepatitis B virus (HBV), is used as a model to study the mechanisms and dynamics of a single-enveloped virus infecting living cells by imaging and tracking at the single-particle level. By monitoring the fluorescent indicator of HBsAg particles, it is found that HBsAg enters cells via a caveolin-mediated endocytic pathway. Tracking of individual HBsAg particles in living cells reveals the anomalously actin-dependent but not microtubule-dependent motility of the internalized HBsAg particle. The motility of HBsAg particles in living cells is also analyzed quantitatively. These results may settle the long-lasting debate of whether HBV directly breaks the plasma membrane barrier or relies on endocytosis to deliver its genome into the cell, and how the virus moves in the cell.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.ispartofpagefrom1212
dc.relation.ispartofpageto1218
dc.relation.ispartofissue9
dc.relation.ispartofjournalSmall
dc.relation.ispartofvolume7
dc.subject.fieldofresearchAnalytical Chemistry not elsewhere classified
dc.subject.fieldofresearchcode030199
dc.titleSingle-particle tracking of hepatitis B virus-like vesicle entry into cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorTang, Zhiyong


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