dc.contributor.author | Gebhardt, Thomas | |
dc.contributor.author | Whitney, Paul G | |
dc.contributor.author | Zaid, Ali | |
dc.contributor.author | Mackay, Laura K | |
dc.contributor.author | Brooks, Andrew G | |
dc.contributor.author | Heath, William R | |
dc.contributor.author | Carbone, Francis R | |
dc.contributor.author | Mueller, Scott N | |
dc.date.accessioned | 2018-04-29T23:43:03Z | |
dc.date.available | 2018-04-29T23:43:03Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0028-0836 | |
dc.identifier.doi | 10.1038/nature10339 | |
dc.identifier.uri | http://hdl.handle.net/10072/173032 | |
dc.description.abstract | Infections localized to peripheral tissues such as the skin result in the priming of T-cell responses that act to control pathogens. Activated T cells undergo migrational imprinting within the draining lymph nodes1, resulting in memory T cells that provide local and systemic protection2. Combinations of migrating and resident memory T cells have been implicated in long-term peripheral immunity, especially at the surfaces that form pathogen entry points into the body3. However, T-cell immunity consists of separate CD4+ helper T cells and CD8+ killer T cells, with distinct effector and memory programming requirements4. Whether these subsets also differ in their ability to form a migrating pool involved in peripheral immunosurveillance or a separate resident population responsible for local infection control has not been explored. Here, using mice, we show key differences in the migration and tissue localization of memory CD4+ and CD8+ T cells following infection of the skin by herpes simplex virus. On resolution of infection, the skin contained two distinct virus-specific memory subsets; a slow-moving population of sequestered CD8+ T cells that were resident in the epidermis and confined largely to the original site of infection, and a dynamic population of CD4+ T cells that trafficked rapidly through the dermis as part of a wider recirculation pattern. Unique homing-molecule expression by recirculating CD4+ T effector-memory cells mirrored their preferential skin-migratory capacity. Overall, these results identify a complexity in memory T-cell migration, illuminating previously unappreciated differences between the CD4+ and CD8+ subsets. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing | |
dc.relation.ispartofpagefrom | 216 | |
dc.relation.ispartofpageto | 219 | |
dc.relation.ispartofjournal | Nature | |
dc.relation.ispartofvolume | 477 | |
dc.subject.fieldofresearch | Immunology not elsewhere classified | |
dc.subject.fieldofresearchcode | 320499 | |
dc.title | Different patterns of peripheral migration by memory CD4+ and CD8+ T cells | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Zaid, Ali | |