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  • Toll-like receptor 2 expression in refractory periapical lesions

    Author(s)
    Desai, SV
    Love, RM
    Rich, AM
    Seymour, GJ
    Griffith University Author(s)
    Love, Robert M.
    Year published
    2011
    Metadata
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    Abstract
    Aim:  To investigate the expression of TLR2 in refractory periapical lesions. Methodology:  Refractory periapical lesion biopsies were histopathologically and clinically categorized into asymptomatic periapical granuloma (n = 10), symptomatic periapical granuloma (n = 10) or periapical cyst (n = 10) and prepared for immunohistochemical staining using antibodies to TLR2, CD3 and CD19 or staining with methyl green pyronin. Sections were viewed under light microscopy and the presence or absence of the target cells was correlated with the histopathological and clinical data. Additionally, TLR2 expression was quantified by ...
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    Aim:  To investigate the expression of TLR2 in refractory periapical lesions. Methodology:  Refractory periapical lesion biopsies were histopathologically and clinically categorized into asymptomatic periapical granuloma (n = 10), symptomatic periapical granuloma (n = 10) or periapical cyst (n = 10) and prepared for immunohistochemical staining using antibodies to TLR2, CD3 and CD19 or staining with methyl green pyronin. Sections were viewed under light microscopy and the presence or absence of the target cells was correlated with the histopathological and clinical data. Additionally, TLR2 expression was quantified by counting TLR+ cells. Results:  Various mononuclear inflammatory cells in the bacteria‐induced periapical lesions were reactive to TLR2 antibody, with many showing morphological similarities to lymphocytes and plasma cells. Lymphocytes were the most numerous cells in the inflammatory infiltrate. In refractory periapical granuloma, CD3+ T cells were more numerous, whereas in periapical cysts, CD19+ B cells were more numerous. There was a statistically significant (P < 0.05) higher expression of TLR2 in symptomatic periapical granuloma than asymptomatic periapical granuloma or periapical cyst. Conclusion:  The presence of TLR‐expressing cells in periapical granulomas and cysts provides further evidence that periapical cysts are likely to be sustained by the immune system via reaction to bacterial antigens.
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    Journal Title
    International Endodontic Journal
    Volume
    44
    Issue
    10
    DOI
    https://doi.org/10.1111/j.1365-2591.2011.01893.x
    Subject
    Dentistry
    Dentistry not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/173093
    Collection
    • Journal articles

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