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dc.contributor.authorMawad, Damia
dc.contributor.authorWarren, Charles
dc.contributor.authorBarton, M.
dc.contributor.authorMahns, David
dc.contributor.authorMorley, John
dc.contributor.authorPham, Binh T.T.
dc.contributor.authorPham, Nguyen T.H.
dc.contributor.authorKueh, Sindy
dc.contributor.authorLauto, Antonio
dc.date.accessioned2018-12-03T23:41:41Z
dc.date.available2018-12-03T23:41:41Z
dc.date.issued2015
dc.identifier.issn0144-8617en_US
dc.identifier.doi10.1016/j.carbpol.2014.12.008en_US
dc.identifier.urihttp://hdl.handle.net/10072/173135
dc.description.abstractEffective tissue bioadhesion of rose bengal–chitosan films can be achieved by photoactivation using a green laser. In this study, lysozyme was incorporated in these films to enhance the rate of depolymerization and assess the laser impact on lysozyme. The lysozyme loaded films exhibited a 21% mass loss after 4 weeks implantation in rats while control films (without lysozyme) had only 7% mass loss. Capillary electrophoresis–mass spectroscopy showed that chitosan degraded into monomers and oligomers of glucosamine and N-acetyl-glucosamine. Irradiation with laser did not affect the depolymerization of adhesive by lysozyme suggesting that the inclusion of lysozyme in the bioadhesive is a viable technique for tailoring the depolymerization.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherPergamon Pressen_US
dc.relation.ispartofpagefrom56en_US
dc.relation.ispartofpageto63en_US
dc.relation.ispartofjournalCarbohydrate Polymersen_US
dc.relation.ispartofvolume121en_US
dc.subject.fieldofresearchSurgeryen_US
dc.subject.fieldofresearchcode110323en_US
dc.titleLysozyme depolymerization of photo-activated chitosan adhesive filmsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text
gro.griffith.authorBarton, Matthew J.


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