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  • Fabrication and Application of Rose Bengal-chitosan Films in Laser Tissue Repair

    Author(s)
    Lauto, Antonio
    Stoodley, Marcus A.
    Barton, M.
    Morley, John
    Mahns, David
    Longo, Leonardo
    Mawad, Damia
    Griffith University Author(s)
    Barton, Matthew J.
    Year published
    2012
    Metadata
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    Abstract
    Photochemical tissue bonding (PTB) is a sutureless technique for tissue repair, which is achieved by applying a solution of rose bengal (RB) between two tissue edges1,2. These are then irradiated by a laser that is selectively absorbed by the RB. The resulting photochemical reactions supposedly crosslink the collagen fibers in the tissue with minimal heat production3. In this report, RB has been incorporated in thin chitosan films to fabricate a novel tissue adhesive that is laser-activated. Adhesive films, based on chitosan and containing ~0.1wt% RB, are fabricated and bonded to calf intestine and rat tibial nerves by a ...
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    Photochemical tissue bonding (PTB) is a sutureless technique for tissue repair, which is achieved by applying a solution of rose bengal (RB) between two tissue edges1,2. These are then irradiated by a laser that is selectively absorbed by the RB. The resulting photochemical reactions supposedly crosslink the collagen fibers in the tissue with minimal heat production3. In this report, RB has been incorporated in thin chitosan films to fabricate a novel tissue adhesive that is laser-activated. Adhesive films, based on chitosan and containing ~0.1wt% RB, are fabricated and bonded to calf intestine and rat tibial nerves by a solid state laser (λ=532 nm, Fluence~110 J/cm2, spot size~0.5 cm). A single-column tensiometer, interfaced with a personal computer, is used to test the bonding strength. The RB-chitosan adhesive bonds firmly to the intestine with a strength of 15 ± 6 kPa, (n=30). The adhesion strength drops to 2 ± 2 (n=30) kPa when the laser is not applied to the adhesive. The anastomosis of tibial nerves can be also completed without the use of sutures. A novel chitosan adhesive has been fabricated that bonds photochemically to tissue and does not require sutures.
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    Journal Title
    Journal of Visualized Experiments
    Volume
    68
    DOI
    https://doi.org/10.3791/4158
    Subject
    Biochemistry and cell biology
    Surgery
    Cognitive and computational psychology
    Publication URI
    http://hdl.handle.net/10072/173142
    Collection
    • Journal articles

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