Show simple item record

dc.contributor.authorLauto, Antonio
dc.contributor.authorStoodley, Marcus A.
dc.contributor.authorBarton, M.
dc.contributor.authorMorley, John
dc.contributor.authorMahns, David
dc.contributor.authorLongo, Leonardo
dc.contributor.authorMawad, Damia
dc.date.accessioned2019-02-04T01:31:11Z
dc.date.available2019-02-04T01:31:11Z
dc.date.issued2012
dc.identifier.issn1940-087X
dc.identifier.doi10.3791/4158
dc.identifier.urihttp://hdl.handle.net/10072/173142
dc.description.abstractPhotochemical tissue bonding (PTB) is a sutureless technique for tissue repair, which is achieved by applying a solution of rose bengal (RB) between two tissue edges1,2. These are then irradiated by a laser that is selectively absorbed by the RB. The resulting photochemical reactions supposedly crosslink the collagen fibers in the tissue with minimal heat production3. In this report, RB has been incorporated in thin chitosan films to fabricate a novel tissue adhesive that is laser-activated. Adhesive films, based on chitosan and containing ~0.1wt% RB, are fabricated and bonded to calf intestine and rat tibial nerves by a solid state laser (λ=532 nm, Fluence~110 J/cm2, spot size~0.5 cm). A single-column tensiometer, interfaced with a personal computer, is used to test the bonding strength. The RB-chitosan adhesive bonds firmly to the intestine with a strength of 15 ± 6 kPa, (n=30). The adhesion strength drops to 2 ± 2 (n=30) kPa when the laser is not applied to the adhesive. The anastomosis of tibial nerves can be also completed without the use of sutures. A novel chitosan adhesive has been fabricated that bonds photochemically to tissue and does not require sutures.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJournal of Visualized Experiments
dc.relation.ispartofpagefrome4158-1
dc.relation.ispartofpagetoe4158-5
dc.relation.ispartofjournalJournal of Visualized Experiments
dc.relation.ispartofvolume68
dc.subject.fieldofresearchSurgery
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode110323
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1701
dc.subject.fieldofresearchcode1702
dc.titleFabrication and Application of Rose Bengal-chitosan Films in Laser Tissue Repair
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorBarton, Matthew J.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record