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dc.contributor.authorNikbakht Nasrabadi, E
dc.contributor.authorJamaluddin, R
dc.contributor.authorAbdul Mutalib, MS
dc.contributor.authorKhaza'ai, H
dc.contributor.authorKhalesi, S
dc.contributor.authorMohd Redzwan, S
dc.date.accessioned2019-02-28T05:44:13Z
dc.date.available2019-02-28T05:44:13Z
dc.date.issued2013
dc.identifier.issn1365-2672
dc.identifier.doi10.1111/jam.12148
dc.identifier.urihttp://hdl.handle.net/10072/173206
dc.description.abstractAims Aflatoxin B1 (AFB1) is considered as the most toxic food contaminant, and microorganisms, especially bacteria, have been studied for their potential to reduce the bioavailability of mycotoxins including aflatoxins. Therefore, this research investigated the efficacy of oral administration of Lactobacillus casei Shirota (LcS) in aflatoxin‐induced rats. Methods and Results Sprague Dawley rats were divided into three groups of untreated control, the group induced with AFB1 only, and the group given probiotic in addition to AFB1. In the group induced with AFB1 only, food intake and body weight were reduced significantly. The liver and kidney enzymes were significantly enhanced in both groups induced with AFB1, but they were lower in the group given LcS. AFB1 was detected from all serum samples except for untreated control group's samples. Blood serum level of AFB1 in the group induced with AFB1 only was significantly higher than the group which received probiotic as a treatment (P < 0·05), and there was no significant difference between the control group and the group treated with probiotic. Conclusions LcS supplementation could improve the adverse effect of AFB1 induction on rats' body weight, plasma biochemical parameters and also could reduce the level of AFB1 in blood serum. Significance and Impact of the Study This study's outcomes contribute to better understanding of the potential of probiotic to reduce the bioavailability ofAFB1. Moreover, it can open an opportunity for future investigations to study the efficacy of oral supplementation of probiotic LcS in reducing aflatoxin level in human.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Ltd
dc.relation.ispartofpagefrom1507
dc.relation.ispartofpageto1515
dc.relation.ispartofissue5
dc.relation.ispartofjournalJournal of Applied Microbiology
dc.relation.ispartofvolume114
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchcode310799
dc.subject.keywordsAflatoxin B1
dc.subject.keywordsChronic aflatoxicosis probiotic
dc.subject.keywordsLactobacillus casei
dc.subject.keywordsShirota
dc.titleReduction of aflatoxin level in aflatoxin-induced rats by the activity of probiotic Lactobacillus casei strain Shirota
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorKhalesi Taharoom, Saman


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