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dc.contributor.authorEdwards, Jennifer L
dc.contributor.authorJennings, Michael P
dc.contributor.authorApicella, Michael A
dc.contributor.authorSeib, Kate L
dc.date.accessioned2018-10-11T01:01:52Z
dc.date.available2018-10-11T01:01:52Z
dc.date.issued2016
dc.identifier.issn1040-841X
dc.identifier.doi10.3109/1040841X.2015.1105782
dc.identifier.urihttp://hdl.handle.net/10072/173229
dc.description.abstractGonorrhea is a major, global public health problem for which there is no vaccine. The continuing emergence of antibiotic-resistant strains raises concerns that untreatable Neisseria gonorrhoeae may become widespread in the near future. Consequently, there is an urgent need for increased efforts towards the development of new anti-gonococcal therapeutics and vaccines, as well as suitable models for potential pre-clinical vaccine trials. Several current issues regarding gonorrhea are discussed herein, including the global burden of disease, the emergence of antibiotic-resistance, the status of vaccine development and, in particular, a focus on the model systems available to evaluate drug and vaccine candidates. Finally, alternative approaches to evaluate vaccine candidates are presented. Such approaches may provide valuable insights into the protective mechanisms, and correlates of protection, required to prevent gonococcal transmission, local infection and disease sequelae.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofpagefrom928
dc.relation.ispartofpageto941
dc.relation.ispartofissue6
dc.relation.ispartofjournalCritical Reviews in Microbiology
dc.relation.ispartofvolume42
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchcode060599
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode1108
dc.titleIs gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 The Author(s). Published by Taylor & Francis.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/Licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
gro.hasfulltextFull Text
gro.griffith.authorJennings, Michael P.
gro.griffith.authorSeib, Kate


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