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  • Tissue-resident T cells: Dynamic players in skin immunity

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    MuellerPUB614.pdf (870.0Kb)
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    Author(s)
    Mueller, Scott N
    Zaid, Ali
    Carbone, Francis R
    Griffith University Author(s)
    Zaid, Ali
    Year published
    2014
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    Abstract
    The skin is a large and complex organ that acts as a critical barrier protecting the body from pathogens in the environment. Numerous heterogeneous populations of immune cells are found within skin, including some that remain resident and others that can enter and exit the skin as part of their migration program. Pathogen-specific CD8+ T cells that persist in the epidermis following infection are a unique population of memory cells with important roles in immune surveillance and protective responses to reinfection. How these tissue-resident memory T cells form in the skin, the signals controlling their persistence and behavior, ...
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    The skin is a large and complex organ that acts as a critical barrier protecting the body from pathogens in the environment. Numerous heterogeneous populations of immune cells are found within skin, including some that remain resident and others that can enter and exit the skin as part of their migration program. Pathogen-specific CD8+ T cells that persist in the epidermis following infection are a unique population of memory cells with important roles in immune surveillance and protective responses to reinfection. How these tissue-resident memory T cells form in the skin, the signals controlling their persistence and behavior, and the mechanisms by which they mediate local recall responses are just beginning to be elucidated. Here, we discuss recent progress in understanding the roles of these skin-resident T cells and also highlight some of the key unanswered questions that need addressing.
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    Journal Title
    Frontiers in Immunology
    Volume
    5
    DOI
    https://doi.org/10.3389/fimmu.2014.00332
    Copyright Statement
    © 2014 Mueller, Zaid and Carbone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Subject
    Immunology not elsewhere classified
    Immunology
    Medical Microbiology
    Publication URI
    http://hdl.handle.net/10072/173452
    Collection
    • Journal articles

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