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dc.contributor.authorKelly, Heath
dc.contributor.authorJacoby, Peter
dc.contributor.authorDixon, Gabriela A
dc.contributor.authorCarcione, Dale
dc.contributor.authorWilliams, Simon
dc.contributor.authorMoore, Hannah C
dc.contributor.authorSmith, David W
dc.contributor.authorKeil, Anthony D
dc.contributor.authorVan Buynder, Paul
dc.contributor.authorRichmond, Peter C
dc.date.accessioned2018-12-03T03:18:54Z
dc.date.available2018-12-03T03:18:54Z
dc.date.issued2011
dc.identifier.issn0891-3668
dc.identifier.doi10.1097/INF.0b013e318201811c
dc.identifier.urihttp://hdl.handle.net/10072/173524
dc.description.abstractBackground: The Western Australian Influenza Vaccine Effectiveness study commenced in 2008 to evaluate a new program to provide free influenza vaccine to all children aged 6 to 59 months. We aimed to assess the protective effect of inactivated influenza vaccination in these children. Methods: We conducted a prospective case–control study in general practices and a hospital emergency department, testing all eligible patients for influenza and a range of other common respiratory viruses. Influenza vaccine effectiveness (VE) against laboratory-confirmed influenza was estimated with cases defined as children with an influenza-like illness who tested positive and controls as those with an influenza-like illness who tested negative for influenza virus. We calculated VE using the adjusted odds ratio from multivariate logistic regression. As a surrogate marker for adequate specimen collection, we explored the difference in VE point estimates defining controls as children in whom another respiratory virus was detected. Results: A total of 75 children were enrolled from general practices and 214 through the emergency department, with 12 (27%) and 36 (17%), respectively, having laboratory-confirmed influenza. Using all the influenza-negative controls, the adjusted VE was 58% (95% confidence interval, 9–81). When controls were limited to those with another virus present, the adjusted VE was 68% (95% confidence interval, 26–86). Conclusions: VE estimates were higher when controls included only those children with another respiratory virus detected. Testing for other common respiratory viruses enables the control group to be restricted to those for whom an adequate sample is likely.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofpagefrom107
dc.relation.ispartofpageto111
dc.relation.ispartofissue2
dc.relation.ispartofjournalPediatric Infectious Disease Journal
dc.relation.ispartofvolume30
dc.subject.fieldofresearchEpidemiology not elsewhere classified
dc.subject.fieldofresearchcode420299
dc.titleVaccine effectiveness against laboratory-confirmed influenza in healthy young children: A case-control study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorVan Buynder, Paul G.


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