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dc.contributor.authorDunne, Eileen M
dc.contributor.authorSmith-Vaughan, Heidi C
dc.contributor.authorRobins-Browne, Roy M
dc.contributor.authorMulholland, E Kim
dc.contributor.authorSatzke, Catherine
dc.date.accessioned2018-11-04T23:21:30Z
dc.date.available2018-11-04T23:21:30Z
dc.date.issued2013
dc.identifier.issn0264-410X
dc.identifier.doi10.1016/j.vaccine.2013.03.024
dc.identifier.urihttp://hdl.handle.net/10072/173566
dc.description.abstractThe nasopharynx of children is often colonised by microorganisms such as Streptococcus pneumoniae (the pneumococcus) that can cause infections including pneumonia and otitis media. In this complex environment, bacteria and viruses may impact each other through antagonistic as well as synergistic interactions. Vaccination may alter colonisation dynamics, evidenced by the rise in non-vaccine serotypes following pneumococcal conjugate vaccination. Discovery of an inverse relationship between S. pneumoniae and Staphylococcus aureus carriage generated concern that pneumococcal vaccination could increase S. aureus carriage and disease. Here we review data on co-colonisation of pathogens in the nasopharynx, focusing on S. pneumoniae and the impact of pneumococcal vaccination. Thus far, pneumococcal vaccination has not had a sustained impact on S. aureus carriage but it is associated with an increase in non-typeable Haemophilus influenzae in acute otitis media aetiology. Advances in bacterial and viral detection methodologies have facilitated research in nasopharyngeal microbiology and will aid investigation of potential vaccine-induced changes, particularly when baseline studies can be conducted prior to pneumococcal vaccine introduction.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom2333
dc.relation.ispartofpageto2342
dc.relation.ispartofissue19
dc.relation.ispartofjournalVaccine
dc.relation.ispartofvolume31
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode060599
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleNasopharyngeal microbial interactions in the era of pneumococcal conjugate vaccination
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSmith-Vaughan, Heidi


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