dc.contributor.author | Lai, Jana YR | |
dc.contributor.author | Cook, Heather | |
dc.contributor.author | Yip, Teem-Wing | |
dc.contributor.author | Berthelsen, Jeanette | |
dc.contributor.author | Gourley, Stephen | |
dc.contributor.author | Krause, Vicki | |
dc.contributor.author | Smith, Helen | |
dc.contributor.author | Leach, Amanda J | |
dc.contributor.author | Smith-Vaughan, Heidi | |
dc.date.accessioned | 2018-01-19T03:46:22Z | |
dc.date.available | 2018-01-19T03:46:22Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1471-2334 | |
dc.identifier.doi | 10.1186/1471-2334-13-409 | |
dc.identifier.uri | http://hdl.handle.net/10072/173567 | |
dc.description.abstract | Background: An outbreak of serotype 1 invasive pneumococcal disease (IPD) occurred in Central Australia from
October 2010 to the latter part of 2012. Surveillance of serotype 1 carriage was conducted to determine
epidemiological features of asymptomatic carriage that could potentially be driving the outbreak.
Methods: 130 patients and accompanying persons presenting at Alice Springs Hospital Emergency Department
consented to nasopharyngeal swab (NPS) collection. NPS were processed by standard methods, including culture,
pneumococcal lytA quantitative real-time PCR, serotype 1-specific real-time PCR and multi-locus sequence
typing (MLST).
Results: Pneumococcal carriage was detected in 16% of participants. Carriage was highest in the under 10 year
olds from remote communities surrounding Alice Springs (75%). Four NPS were positive for serotype 1 DNA by
PCR; 3 were also culture-positive for serotype 1 pneumococci. Serotype 1 isolates had atypical colony morphology
on primary culture. All serotype 1 carriers were healthy children 5 to 8 years of age from remote communities.
By MLST, serotype 1 isolates were ST306, as were IPD isolates associated with this outbreak.
Conclusions: During an outbreak of serotype 1 ST306 IPD, carriage of the outbreak strain was detected in 3% NPS
collected. All carriers were healthy children 5 to 8 years of age. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BioMed Central | |
dc.relation.ispartofpagefrom | 409-1 | |
dc.relation.ispartofpageto | 409-7 | |
dc.relation.ispartofjournal | BMC Infectious Diseases | |
dc.relation.ispartofvolume | 13 | |
dc.subject.fieldofresearch | Microbiology | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Medical microbiology | |
dc.subject.fieldofresearchcode | 3107 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 3207 | |
dc.title | Surveillance of pneumococcal serotype 1 carriage during an outbreak of serotype 1 invasive pneumococcal disease in central Australia 2010-2012 | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by/2.0 | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © 2013 Lai et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Smith-Vaughan, Heidi | |