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dc.contributor.authorLai, Jana YR
dc.contributor.authorCook, Heather
dc.contributor.authorYip, Teem-Wing
dc.contributor.authorBerthelsen, Jeanette
dc.contributor.authorGourley, Stephen
dc.contributor.authorKrause, Vicki
dc.contributor.authorSmith, Helen
dc.contributor.authorLeach, Amanda J
dc.contributor.authorSmith-Vaughan, Heidi
dc.date.accessioned2018-01-19T03:46:22Z
dc.date.available2018-01-19T03:46:22Z
dc.date.issued2013
dc.identifier.issn1471-2334
dc.identifier.doi10.1186/1471-2334-13-409
dc.identifier.urihttp://hdl.handle.net/10072/173567
dc.description.abstractBackground: An outbreak of serotype 1 invasive pneumococcal disease (IPD) occurred in Central Australia from October 2010 to the latter part of 2012. Surveillance of serotype 1 carriage was conducted to determine epidemiological features of asymptomatic carriage that could potentially be driving the outbreak. Methods: 130 patients and accompanying persons presenting at Alice Springs Hospital Emergency Department consented to nasopharyngeal swab (NPS) collection. NPS were processed by standard methods, including culture, pneumococcal lytA quantitative real-time PCR, serotype 1-specific real-time PCR and multi-locus sequence typing (MLST). Results: Pneumococcal carriage was detected in 16% of participants. Carriage was highest in the under 10 year olds from remote communities surrounding Alice Springs (75%). Four NPS were positive for serotype 1 DNA by PCR; 3 were also culture-positive for serotype 1 pneumococci. Serotype 1 isolates had atypical colony morphology on primary culture. All serotype 1 carriers were healthy children 5 to 8 years of age from remote communities. By MLST, serotype 1 isolates were ST306, as were IPD isolates associated with this outbreak. Conclusions: During an outbreak of serotype 1 ST306 IPD, carriage of the outbreak strain was detected in 3% NPS collected. All carriers were healthy children 5 to 8 years of age.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofpagefrom409-1
dc.relation.ispartofpageto409-7
dc.relation.ispartofjournalBMC Infectious Diseases
dc.relation.ispartofvolume13
dc.subject.fieldofresearchPublic Health and Health Services not elsewhere classified
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchcode111799
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1108
dc.titleSurveillance of pneumococcal serotype 1 carriage during an outbreak of serotype 1 invasive pneumococcal disease in central Australia 2010-2012
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2013 Lai et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorSmith-Vaughan, Heidi


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