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dc.contributor.authorChang, Anne B
dc.contributor.authorMarsh, Robyn L
dc.contributor.authorSmith-Vaughan, Heidi C
dc.contributor.authorHoffman, Lucas R
dc.date.accessioned2017-12-19T00:39:02Z
dc.date.available2017-12-19T00:39:02Z
dc.date.issued2012
dc.identifier.issn1472-8214
dc.identifier.doi10.1517/14728214.2012.702755
dc.identifier.urihttp://hdl.handle.net/10072/173568
dc.description.abstractIntroduction: The global burden of disease due to bronchiectasis is high, disproportionately impacting developing countries and disadvantaged populations. Bronchiectasis, the destruction and dilation of airways, is due to a variety of causes and is characterized by a self-perpetuating cycle of airway inflammation, infection and obstruction that results in substantial morbidity and mortality. Although many therapies have been tested that address each of these three components, as well as the diseases that both cause and result from bronchiectasis, there have been few randomized, placebo-controlled trials. Areas covered: In this review, current knowledge of the clinical features, pathophysiology and epidemiology of bronchiectasis among both adults and children is summarized. We discuss the quality and extent of evidence supporting current treatment strategies, focusing on therapies for which the strongest evidence of efficacy exists. We then identify key goals for future research on the causes and treatments of a variety of types of bronchiectasis. Expert opinion: Significant advances in the prevention and treatment of bronchiectasis will require substantially improved understanding of the pathogenesis of this orphan disease. A concerted, global effort to coordinate studies of both the pathophysiology and potential treatments of bronchiectasis, in its many forms, could lead to substantial improvements in outcomes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherTaylor & Francis
dc.relation.ispartofpagefrom361
dc.relation.ispartofpageto378
dc.relation.ispartofissue3
dc.relation.ispartofjournalExpert Opinion on Emerging Drugs
dc.relation.ispartofvolume17
dc.subject.fieldofresearchRespiratory Diseases
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode110203
dc.subject.fieldofresearchcode1115
dc.titleEmerging drugs for bronchiectasis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSmith-Vaughan, Heidi


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