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dc.contributor.authorLam, Alfred King Yin
dc.contributor.authorLo, Chung Yau
dc.contributor.authorLeung, Pauline
dc.contributor.authorLang, Brian Hung Hin
dc.contributor.authorChan, Wai Fun
dc.contributor.authorLuk, John M
dc.contributor.editorCharles M. Balch
dc.date.accessioned2017-05-03T14:35:50Z
dc.date.available2017-05-03T14:35:50Z
dc.date.issued2007
dc.identifier.issn1068-9265
dc.identifier.doi10.1245/s10434-006-9280-9
dc.identifier.urihttp://hdl.handle.net/10072/17362
dc.description.abstractBackground Alterations of the p16 gene are common in human cancers, but their roles in thyroid cancers have not been clearly defined. The aim of the present study was to investigate the clinicopathological roles of the p16 gene in papillary thyroid carcinoma (PTC). Methods p16 gene alterations were investigated in 44 patients with PTC (9 men, 35 women) by immunohistochemistry, reverse transcriptase-polymerase chain reaction and methylation-specific polymerase chain reaction. The findings were correlated with their clinicopathological features. Results p16 protein expression, mRNA alterations, and promoter methylation were detected in 89% (n = 39), 77% (n = 33), and 41% (n = 18) of patients with PTC, respectively. There was no marked relationship between p16 protein expression, mRNA alteration, and promoter methylation. In follicular variant of PTC (FVPTC), there was a frequent lack of p16 protein expression and promoter methylation. PTCs showing p16 promoter methylation were often associated with a high AMES (age, metastasis to distant sites, extrathyroidal invasion, size) risk group and advanced pTNM (tumor-lymph node-metastasis) stages. Conclusions p16 gene alterations are common and correlate with histological features and biological aggressiveness in PTC, suggesting that they might play an important role in its pathogenesis.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science
dc.publisher.placeUSA
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1772
dc.relation.ispartofpageto1779
dc.relation.ispartofissue5
dc.relation.ispartofjournalAnnals of Surgical Oncology
dc.relation.ispartofvolume14
dc.rights.retentionY
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.titleClinicopathological roles of alterations of tumor suppressor gene p16 in papillary thyroid carcinoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-06-05T03:51:30Z
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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