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  • Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse

    Author(s)
    Cuffe, JSM
    Dickinson, H
    Simmons, DG
    Moritz, KM
    Griffith University Author(s)
    Cuffe, James S.
    Year published
    2011
    Metadata
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    Abstract
    Objectives: Maternal glucocorticoid (GC) exposure during pregnancy can alter fetal development and program the onset of disease in adult offspring. The placenta helps protect the fetus from excess GC exposure but is itself susceptible to maternal insults and may be involved in sex dependant regulation of fetal programming. This study aimed to investigate the effects of maternal GC exposure on the developing placenta. Study design and main outcome measures: Pregnant mice were treated with dexamethasone (DEX-1 mg/ kg/h) or saline (SAL) for 60 h via minipump beginning at E12.5. Placentas were collected at E14.5 and E17.5 and ...
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    Objectives: Maternal glucocorticoid (GC) exposure during pregnancy can alter fetal development and program the onset of disease in adult offspring. The placenta helps protect the fetus from excess GC exposure but is itself susceptible to maternal insults and may be involved in sex dependant regulation of fetal programming. This study aimed to investigate the effects of maternal GC exposure on the developing placenta. Study design and main outcome measures: Pregnant mice were treated with dexamethasone (DEX-1 mg/ kg/h) or saline (SAL) for 60 h via minipump beginning at E12.5. Placentas were collected at E14.5 and E17.5 and the expression of growth factors and placental transporters examined by real-time PCR and/or Western blot. Histological analysis was performed to assess for morphological changes. Results: At E14.5, DEX exposed male and female fetuses had a lower weight compared to SAL animals but placental weight was lower in females only. Hsd11b2 and Vegfa gene expression was increased and MAPK1 protein expression decreased in the placentas of females only. At E17.5 placental and fetal body weights were similar and differences in MAPK were no longer present although HSD11B2 protein was elevated in placentas of DEX females. Levels of glucose or amino acid transporters were unaffected. Conclusions: Results suggest sex specific responses to maternal GCs within the placenta. Decreased levels of MAPK protein in placentas of female fetuses suggest alterations in the MAPK pathway may contribute to the lower placental weights in this sex. This may contribute towards sex specific fetal programming of adult disease.
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    Journal Title
    Placenta
    Volume
    32
    Issue
    12
    DOI
    https://doi.org/10.1016/j.placenta.2011.09.009
    Subject
    Biochemistry and cell biology
    Clinical sciences
    Clinical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/173669
    Collection
    • Journal articles

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