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dc.contributor.authorIslam, S.
dc.contributor.authorKenah, E.
dc.contributor.authorBhuiyan, M.A.A.
dc.contributor.authorRahman, Kazi M.
dc.contributor.authorGoodhew, B.
dc.contributor.authorGhalib, C.M.
dc.contributor.authorZahid, M.M.
dc.contributor.authorOzaki, M.
dc.contributor.authorRahman, M.W.
dc.contributor.authorHaque, R.
dc.contributor.authorLuby, S.P.
dc.contributor.authorMaguire, J.H.
dc.contributor.authorMartin, D.
dc.contributor.authorBern, C.
dc.date.accessioned2018-05-22T07:18:13Z
dc.date.available2018-05-22T07:18:13Z
dc.date.issued2013
dc.identifier.issn0002-9637
dc.identifier.doi10.4269/ajtmh.12-0711
dc.identifier.urihttp://hdl.handle.net/10072/173691
dc.description.abstractWe conducted active surveillance for kala-azar and post–kala-azar dermal leishmaniasis (PKDL) in a population of 24,814 individuals. Between 2002 and 2010, 1,002 kala-azar and 185 PKDL cases occurred. Median PKDL patient age was 12 years; 9% had no antecedent kala-azar. Cases per 10,000 person-years peaked at 90 for kala-azar (2005) and 28 for PKDL (2007). Cumulative PKDL incidence among kala-azar patients was 17% by 5 years. Kala-azar patients younger than 15 years were more likely than older patients to develop PKDL; no other risk factors were identified. The most common lesions were hypopigmented macules. Of 98 untreated PKDL patients, 48 (49%) patients had resolution, with median time of 19 months. Kala-azar patients showed elevated interferon-γ (IFNγ), tumor necrosis factor-α (TNFα), and interleukin 10 (IL-10). Matrix metalloproteinase 9 (MMP9) and MMP9/tissue inhibitor of matrix metalloproteinase-1 (TIMP1) ratio were significantly higher in PKDL patients than in other groups. PKDL is frequent in Bangladesh and poses a challenge to the current visceral leishmaniasis elimination initiative in the Indian subcontinent.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherThe American Society of Tropical Medicine and Hygiene
dc.relation.ispartofpagefrom345
dc.relation.ispartofpageto353
dc.relation.ispartofissue2
dc.relation.ispartofjournalAmerican Journal of Tropical Medicine and Hygiene
dc.relation.ispartofvolume89
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320299
dc.titleClinical and Immunological Aspects of Post-Kala-Azar Dermal Leishmaniasis in Bangladesh
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2013 American Society of Tropical Medicine and Hygiene. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorRahman, Kazi M.


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