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dc.contributor.authorChung, Yvonne
dc.contributor.authorLam, Alfred KY
dc.contributor.authorLuk, John M
dc.contributor.authorLaw, Simon
dc.contributor.authorChan, Kwok-Wah
dc.contributor.authorLee, Ping-Yin
dc.contributor.authorWong, John
dc.contributor.editorYvonne Chan
dc.date.accessioned2017-05-03T14:35:30Z
dc.date.available2017-05-03T14:35:30Z
dc.date.issued2007
dc.identifier.issn1068-9265
dc.identifier.doi10.1245/s10434-007-9511-8
dc.identifier.urihttp://hdl.handle.net/10072/17373
dc.description.abstractBackground E-cadherin is a well-known tumor suppressor and its dysregulated expression correlates with tumor differentiation, metastasis and survival in esophageal squamous cell carcinoma (ESCC). p120 catenin is an Armadillo protein normally bound to E-cadherin in the cadherin-catenin complex at the adherens junction. Dysregulated expression and mislocalization of p120ctn affect the protective function of the complex. The objective of the present study was to evaluate the clinical significance of E-cadherin and p120ctn expression in ESCC. Methods Immunohistochemistry was performed to investigate the expression of E-cadherin and p120ctn proteins in 71 patients with ESCC. The relationships between protein expression and clinicopathological characteristics were analyzed. Results Reduced E-cadherin and p120ctn expressions were observed in 42.3% and 8.5% of ESCC cases, respectively. Reduction of membranous p120ctn was observed in 33.8% of cases. Membranous E-cadherin was preserved when p120ctn co-localized on the membrane of tumor cells (72.3%, P = 0.001). High level E-cadherin expression and membranous p120ctn preservation positively correlated with tumor differentiation (P = 0.001 and P = 0.008, respectively). p120ctn expression was also significantly related to lymph node metastasis (P = 0.003). Heterogeneous expression of both E-cadherin and p120ctn was observed in dysplasia. Conclusions Altered E-cadherin expression and p120ctn localization were related to tumor differentiation, indicating their important roles in the pathogenesis of ESCC.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeNew York
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3260
dc.relation.ispartofpageto3267
dc.relation.ispartofissue11
dc.relation.ispartofjournalAnnals of Surgical Oncology
dc.relation.ispartofvolume14
dc.rights.retentionY
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.titleAltered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-02-06T01:35:38Z
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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